蓝花威灵仙（Hygrophila schulli）在当地被称为“Neermulli”，是斯里兰卡的一种草本植物。古代草药文献显示，蓝花威灵仙的整株植物或其部分可用于治疗不同的传染性和非传染性疾病，包括糖尿病和结核病。已经确定了具有抗微生物、抗肿瘤、抗氧化、肝保护、驱虫、肾保护、抗糖尿病、抗白内障、抗炎症、抗痛觉、造血、利尿、抗尿石、退热、神经保护和抗内毒素活性的活性成分和次生代谢产物，包括生物碱、单宁、类固醇、蛋白质、黄酮类和糖苷。在本综述中，我们对从最早发现的1886年到2021年底的临床研究、专利和分析研究进行了综述。我们对蓝花威灵仙植物提取物的生物活性和化学成分进行了批判性分析，并尝试总结这些信息，以便今后在这个领域的研究人员能够加以利用。

Hygrophila schulli which is known as "Neermulli'' in the vernacular is an herbaceous plant native to Sri Lanka. Ancient medicinal literature suggests the use of H. schulli whole plant or its parts for the treatment of different communicable and non-communicable diseases including diabetes mellitus and tuberculosis. Active constituents and secondary metabolites including alkaloids, tannins, steroids, proteins, flavonoids, and glycosides are identified to possess antimicrobial, antitumor, antioxidant, hepatoprotective, anthelmintic, nephroprotective, antidiabetic, anticataract, anti-inflammatory, anti-nociceptive, hematopoietic, diuretic, antiurolithiatic, antipyretic, neuroprotection, and anti-endotoxin activities. In this review, we reviewed clinical studies, patents, and analytical studies from the earliest found examples from 1886 to the end of 2021. We critically analyzed and attempt to summarize the information based on bioactivities and chemical composition of H. schulli plant extracts which will be of future use for researchers in this field.