糖尿病在结直肠癌患者中的患病率较高，这一点很重要，因为糖尿病被认为是提高死亡率的危险因素。本研究调查了合并发生的糖尿病相关并发症对年长的合并糖尿病结直肠癌患者的全因五年死亡率的影响。本研究使用2008年至2019年的全国医疗保险服务数据，识别了60岁及以上被诊断为2型糖尿病的结直肠癌患者。结果测量指标为全因五年死亡率。主要自变量为使用糖尿病并发症严重程度指数（DCSI）的糖尿病相关并发症的发生情况。除了计算风险差异外，还使用Cox比例风险模型进行生存分析。根据并发症类型和DCSI评分进行亚组分析。在1312个个体中，319人（24.3%）在结直肠癌诊断后一年内的五年内死亡。在合并糖尿病及发生糖尿病相关并发症的病患中，死亡风险较高（风险比1.29，95%置信区间1.03-1.63）。不论并发症类型和DCSI评分如何，这些趋势一般都得以保持。结直肠癌诊断后发生的糖尿病相关并发症与老年结直肠癌患者和已有糖尿病患者的全因五年死亡风险增加有关。©2023作者，独家许可授予施普林格费尔拉格德意大利，施普林格自然出版集团的组成部分。

The prevalence of diabetes is higher in patients with colorectal cancer, which is important because diabetes is recognized as a risk factor for increased mortality. This study investigated the impact of incident diabetes-related complications on all-cause five-year mortality in older aged colorectal cancer patients with diabetes.The 2008 to 2019 National Health Insurance Service data on the elderly were used to identify patients with colorectal cancer aged 60 years or above diagnosed with type 2 diabetes mellitus. The outcome measure was all-cause five-year mortality. The main independent variable was incident status of diabetes-related complications using the Diabetes Complications Severity Index (DCSI). Survival analyses were performed using the Cox proportional hazards model, in addition to the calculation of risk differences. Subgroup analysis was conducted based on the type of complication and DCSI scores.Among 1,312 individuals, 319 (24.3%) died within five years after one year of a cancer diagnosis. The risk of mortality was higher in patients with diabetes and cancer having incident diabetes-related complications (Hazard Ratio 1.29, 95% Confidence Interval 1.03-1.63). These tendencies were generally maintained regardless of the type of complication and DCSI scores.The incidence of diabetes-related complications after cancer diagnosis was associated with an increased risk of all-cause five-year mortality in older patients with colorectal cancer and preexisting diabetes.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.