硒可以通过其在硒酶中的结合来对抗炎症；因此，在本研究中，我们通过对随机对照试验（RCTs）进行系统回顾和荟萃分析，评估了静脉注射硒对C-反应蛋白（CRP）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）的影响。我们在PubMed、Scopus、Cochrane、clinicaltrials.gov和ISI Web of Science等数据库中进行了系统搜索，截至2022年10月，对于研究地点或出版时间没有限制。我们通过所选炎症介质血清浓度的基线平均变化和标准偏差来计算效应量。采用DerSimonian和Laird随机效应模型估计异质性和总体效应的摘要。本系统回顾和荟萃分析的研究包括10个RCTs和8个RCTs。我们的结果显示，静脉注射硒明显降低了血清IL-6的浓度（加权平均差异（WMD）= -3.85 pg/ml；95%可信区间（CI）= -7.37，-0.34 pg/ml；p = 0.032），但与对照组相比，对CRP的血清水平没有显著改变（WMD = 4.58 mg/L；95% CI = -6.11，15.27 mg/L；P = 0.401）。根据我们的结果，静脉注射硒补充剂可能降低炎症介质的血清水平。 © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Selenium can protect against inflammation through its incorporation in selenoenzymes; therefore, in this study, we assessed the effect of parenteral selenium on C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) through a systematic review and meta-analysis on randomized controlled trials (RCTs). A systematic search was performed in the databases, including PubMed, Scopus, Cochrane, clinicaltrials.gov, and ISI Web of Science, up to October 2022, with no limitation in study location or publication time. We calculated the effect size by the mean change from baseline in serum concentration of selected inflammatory mediators and their standard deviations. DerSimonian and Laird random effects model was used to estimate the heterogeneity and summary of the overall effects. Included studies in this systematic review and meta-analysis were 10 and 8 RCTs, respectively. Our results revealed parenteral selenium significantly decreased serum IL-6 (Weighted Mean Difference (WMD) = -3.85 pg/ml; 95% confidence interval (CI) = -7.37, -0.34 pg/ml; p = 0.032) but did not significantly change serum levels of CRP (WMD = 4.58 mg/L; 95% CI = -6.11, 15.27 mg/L; P = 0.401) compared to the comparison groups. According to our results, parenteral selenium supplementation might reduce serum levels of inflammatory mediators.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.