阿尔茨海默病（AD）是科学界迫切需要的病理之一。本研究的目的是调查地西泮结合抑制因子（DBI）作为AD预后的预后因素。将120名参与者分为3组进行研究。研究包括40名新诊断的阿尔茨海默患者（NDG），他们已经被诊断出患有AD但尚未接受治疗，40名患有5年前被诊断的患者（D5YG），以及40名健康对照组（CG）。比较了3组之间的DBI、氧化应激、炎症和神经退行性生物标志物的水平。与CG相比，D5YG和NDG的血浆中DBI、寡聚Aβ、总tau、胶质纤维酸性蛋白、α-突触核蛋白、白细胞介素（IL）1β、IL6、肿瘤坏死因子α、氧化应激指数、高敏感C-反应蛋白和DNA损伤的水平较高（p < 0.001）。相反，D5YG和NDG的血浆中总硫醇、天然硫醇、维生素D和维生素B12的水平较低（p < 0.001）。DBI可能是AD的潜在血浆生物标志物和有前途的药物靶点。它可以帮助医生通过认知和神经退行性测试进行全面评估。© 2023 S. Karger AG, Basel.

Alzheimer's disease (AD) is one of the pathologies that the scientific world is still desperate for. The aim of this study was the investigation of diazepam binding inhibitor (DBI) as a prognostic factor for AD prognosis.A total of 120 participants were divided into 3 groups. Forty new diagnosed Alzheimer patients (NDG) who have been diagnosed but have not started AD treatment, 40 patients who diagnosed 5 years ago (D5YG), and 40 healthy control groups (CG) were included in the study. Levels of DBI, oxidative stress, inflammatory, and neurodegenerative biomarkers were compared between 3 groups.Plasma levels of DBI, oligomeric Aβ, total tau, glial fibrillary acidic protein, α-synuclein, interleukin (IL) 1β, IL6, tumor necrosis factor α, oxidative stress index, high-sensitive C-reactive protein, and DNA damage were found higher in D5YG and NDG as compared to CG (p < 0.001). On the contrary, plasma levels of total thiol, native thiol, vitamin D and vitamin B12 were lower in D5YG and NDG as compared to CG (p < 0.001).DBI may be a potential plasma biomarker and promising drug target for AD. It could help physicians make a comprehensive evaluation with cognitive and neurodegenerative tests.© 2023 S. Karger AG, Basel.