豚鼠中不常见尿道膀胱肿瘤，但近年来诊断病例数量有所增加。本文作者介绍了三例被转诊的宠物豚鼠原发性尿道膀胱肿瘤的病例，诊断方法包括诊断影像学（CT、放射学和超声学）和探查性腹腔镜手术。由于第一例肿瘤位于尿道膀胱颈部且所有者选择术中安乐死，手术切除无法实施。而第二和第三例均为肿瘤起源于尿道膀胱顶部。第三只豚鼠在手术中心脏骤停，复苏无效。第二例中，肿瘤经部分膀胱切除术后得到切除，术后一个月进行超声检查未显示肿瘤复发迹象。延迟发现是负面结果的主要原因，因为这时肿瘤已经变得很大和广泛。如果出现持续的血尿症状且已排除尿结石，请进行超声检查以确定是否为尿道膀胱肿瘤所致。对于豚鼠的检查应定期安排，当初诊不确定的情况下，临床表现模糊时，晚期治疗会显著降低结果与生存率。版权所有 © 2023 年。Elsevier Inc. 发表。

Urinary bladder tumors are not common in guinea pigs, but case numbers being diagnosed have increased in the past years. The authors present three referred cases of primary urinary bladder tumors in pet guinea pigs diagnosed using diagnostic imaging (CT, radiography and ultrasonography) and exploratory laparotomy. Excision was not possible in the first case as the tumor was located at the neck of the urinary bladder and the owner opted for intraoperative euthanasia. The second and third cases both had tumors originating from the apex of the urinary bladder. The third guinea pig went into cardiac arrest during surgery and resuscitation was unsuccessful. The tumor was removed from the urinary bladder using partial cystectomy in the second case and one-month post-surgery ultrasonographic examination showed no signs of tumor reoccurrence. Late recognition is the main reason for a negative outcome, as by this time tumors are already large and extensive. Whenever prolonged symptoms of hematuria are present and urolithiasis has been ruled out, ultrasonography should be undertaken to determine if a urinary tumor is the cause. Rechecks should be scheduled on a regular basis for guinea pigs when a definitive diagnosis cannot not be made at initial presentation for vague clinical signs, as outcome and survival can reduce significantly when definitive treatment is delayed.Copyright © 2023. Published by Elsevier Inc.