癌相关成纤维细胞（CAFs）是肿瘤微环境的重要组成部分，参与了癌症进展的多个方面，并被认为是肿瘤免疫逃逸的贡献者。CAFs表现出一种独特的耐辐射表型，能够在临床放疗剂量下存活；然而，电离辐射可以诱导它们的分泌发生变化，并通过作用于肿瘤和免疫细胞来影响肿瘤进展。在本综述中，我们描述了放射治疗对CAFs的影响的现有知识，并总结了CAFs、肿瘤细胞和免疫细胞之间的相互作用的理解。我们突出了CAFs在放射治疗抵抗中的重要作用，并讨论了针对CAFs的当前和未来的放射治疗策略。© 2023. 作者们。

Cancer-associated fibroblasts (CAFs) are an important component of the tumor microenvironment that are involved in multiple aspects of cancer progression and considered contributors to tumor immune escape. CAFs exhibit a unique radiation resistance phenotype, and can survive clinical radiation doses; however, ionizing radiation can induce changes in their secretions and influence tumor progression by acting on tumor and immune cells. In this review, we describe current knowledge of the effects of radiation therapies on CAFs, as well as summarizing understanding of crosstalk among CAFs, tumor cells, and immune cells. We highlight the important role of CAFs in radiotherapy resistance, and discuss current and future radiotherapy strategies for targeting CAFs.© 2023. The Author(s).