F18-氟脱氧葡萄糖正电子发射断层成像/计算机断层成像（FDG PET/CT）在肿瘤诊断、分期和治疗反应评估中发挥至关重要的作用，广泛应用于临床肿瘤学实践已有多年。然而，由于FDG亲和性低或干扰性的生理背景活性，它在评估某些特定的胃肠癌类型方面存在一定局限性。成纤维细胞激活蛋白（FAP）是肿瘤微环境中的一种蛋白质，在多种癌症中高度过表达，这使其成为肿瘤成像和治疗的有吸引力的靶点。最近，FAP靶向放射性药物在临床研究中广泛应用，并在肿瘤成像方面取得了良好的效果。考虑到FDG PET/CT的局限性以及肝脏和肠道环路中缺乏生理性FAP靶向示踪剂的摄取，胃肠癌是FAP靶向成像最有前景的应用之一。在本文中，我们对胃肠癌中的FAP靶向成像进行了综述，以阐明这类分子在胃肠肿瘤学领域中的当前和潜在未来作用。© 2023. 国际癌症成像学会（ICIS）。

F18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) plays a crucial role in tumour diagnosis, staging, and therapy response evaluation of various cancer types and has been a standard imaging modality used in clinical oncology practice for many years. However, it has certain limitations in evaluating some particular gastrointestinal cancer types due to low FDG-avidity or interphering physiological background activity. Fibroblast activation protein (FAP), a protein of the tumour microenvironment, is overexpressed in a wide range of cancers which makes it an attractive target for both tumour imaging and therapy. Recently, FAP-targeted radiopharmaceuticals are widely used in clinical research and achieved great results in tumour imaging. Considering the limitations of FDG PET/CT and the lack of physiological FAP-targeted tracer uptake in liver and intestinal loops, gastrointestinal cancers are among the most promising indications of FAP-targeted imaging. Herein, we present a comprehensive review of FAP-targeted imaging in gastrointestinal cancers in order to clarify the current and potential future role of this class of molecules in gastrointestinal oncology.© 2023. International Cancer Imaging Society (ICIS).