研究动态
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消化道恶性肿瘤的靶向FAP PET成像:综述.

FAP-targeted PET imaging in gastrointestinal malignancies: a comprehensive review.

发表日期:2023 Aug 22
作者: Ayça Arçay Öztürk, Patrick Flamen
来源: CANCER IMAGING

摘要:

F18-氟脱氧葡萄糖正电子发射断层成像/计算机断层成像(FDG PET/CT)在肿瘤诊断、分期和治疗反应评估中发挥至关重要的作用,广泛应用于临床肿瘤学实践已有多年。然而,由于FDG亲和性低或干扰性的生理背景活性,它在评估某些特定的胃肠癌类型方面存在一定局限性。成纤维细胞激活蛋白(FAP)是肿瘤微环境中的一种蛋白质,在多种癌症中高度过表达,这使其成为肿瘤成像和治疗的有吸引力的靶点。最近,FAP靶向放射性药物在临床研究中广泛应用,并在肿瘤成像方面取得了良好的效果。考虑到FDG PET/CT的局限性以及肝脏和肠道环路中缺乏生理性FAP靶向示踪剂的摄取,胃肠癌是FAP靶向成像最有前景的应用之一。在本文中,我们对胃肠癌中的FAP靶向成像进行了综述,以阐明这类分子在胃肠肿瘤学领域中的当前和潜在未来作用。© 2023. 国际癌症成像学会(ICIS)。
F18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) plays a crucial role in tumour diagnosis, staging, and therapy response evaluation of various cancer types and has been a standard imaging modality used in clinical oncology practice for many years. However, it has certain limitations in evaluating some particular gastrointestinal cancer types due to low FDG-avidity or interphering physiological background activity. Fibroblast activation protein (FAP), a protein of the tumour microenvironment, is overexpressed in a wide range of cancers which makes it an attractive target for both tumour imaging and therapy. Recently, FAP-targeted radiopharmaceuticals are widely used in clinical research and achieved great results in tumour imaging. Considering the limitations of FDG PET/CT and the lack of physiological FAP-targeted tracer uptake in liver and intestinal loops, gastrointestinal cancers are among the most promising indications of FAP-targeted imaging. Herein, we present a comprehensive review of FAP-targeted imaging in gastrointestinal cancers in order to clarify the current and potential future role of this class of molecules in gastrointestinal oncology.© 2023. International Cancer Imaging Society (ICIS).