我们分析了33例进行手术和辅助治疗的恶性胶质瘤患者的血浆β-前突索质蛋白（β-前突索质蛋白），胶质纤维酸性蛋白（GFAP）和神经丝蛋白（NfL和NfH）的长期浓度和预后作用。与其他肿瘤病例相比，胶质母细胞瘤患者的GFAP和NfL水平升高。β-前突索质蛋白，NfL和NfH在手术后增加，而GFAP在长期随访中减少。β-前突索质蛋白和神经丝蛋白浓度受手术和/或放疗方案的影响。GFAP和神经丝蛋白水平与生存率显著相关。恶性胶质瘤类型的血浆神经元和星形胶质生物标志物在手术和辅助治疗后显示出不同的变化轨迹。 © 2023 The Authors. Annals of Clinical and Translational Neurology由Wiley Periodicals LLC代表美国神经学协会出版。

We analyzed the longitudinal concentrations and prognostic roles of plasma β-synuclein (β-syn), glial fibrillary acidic protein (GFAP), and neurofilament proteins (NfL and NfH) in 33 patients with malignant gliomas, who underwent surgical and adjuvant therapy. GFAP and NfL levels were increased in patients with glioblastoma compared to cases with other tumors. β-syn, NfL and NfH increased after surgery, whereas GFAP decreased at long-term follow-up. β-syn and neurofilament concentrations were influenced by surgery and/or radiotherapy regimens. GFAP and neurofilament levels were significantly associated with survival. Plasma neuronal and astrocytic biomarkers are differentially altered in malignant glioma types and displayed distinct trajectories after surgical and adjuvant therapy.© 2023 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.