肥胖是一种全球性趋势且逐渐加重的多因素疾病流行病，与多种共病同时出现，这些共病是恶性心脏重塑和疾病的危险因素。高强度间歇训练（HIIT）因其对超重和肥胖个体的心脏代谢健康有利的结果而受到广泛关注。本综述的主要目的是讨论HIIT如何改善肥胖个体的心脏损伤的基本过程，以开发肥胖管理的可行治疗方法。在本综述中，我们从最早的记录至2013年1月进行了多数据库搜索和汇集，以收集与HIIT干预超重/肥胖人类和动物相关的心脏重塑和健康研究的定性组分。我们试图将HIIT在肥胖心脏重塑改善中的主要机制整合为一个总体的连续假设。本研究的重点是探讨HIIT对肥胖所致心脏重塑的改善作用，包括脂肪分布、能量代谢、炎症反应、胰岛素抵抗以及肥胖相关危险因素的多效机制。总之，HIIT已被证明能减少肥胖所致心脏重塑的风险，但目前尚不清楚HIIT对肥胖所致心脏损伤和疾病的长期效果。综合了解强调了在确认HIIT的安全性和有效性并在肥胖患者中广泛应用之前，有许多具体的研究是必需的。版权所有© 2023年 Bo, Guo, Kaila, Hao, Zhang, Wei和Yao.

Obesity is a global and rising multifactorial pandemic associated with the emergence of several comorbidities that are risk factors for malignant cardiac remodeling and disease. High-intensity interval training (HIIT) has gained considerable attention due to its favorable outcomes of cardiometabolic health in individuals with overweight or obese. The primary aim of this review is to discuss the fundamental processes through which HIIT improves cardiac impairment in individuals with obesity to develop viable treatments for obesity management. In this review, a multiple database search and collection were conducted from the earliest record to January 2013 for studies included the qualitative component of HIIT intervention in humans and animals with overweight/obesity related to cardiac remodeling and fitness. We attempt to integrate the main mechanisms of HIIT in cardiac remolding improvement in obesity into an overall sequential hypothesis. This work focus on the ameliorative effects of HIIT on obesity-induced cardiac remodeling with respect to potential and pleiotropic mechanisms, including adipose distribution, energy metabolism, inflammatory response, insulin resistance, and related risk profiles in obesity. In conclusion, HIIT has been shown to reduce obesity-induced risks of cardiac remodeling, but the long-term effects of HIIT on obesity-induced cardiac injury and disease are presently unknown. Collective understanding highlights numerous specific research that are needed before the safety and effectiveness of HIIT can be confirmed and widely adopted in patient with obesity.Copyright © 2023 Bo, Guo, Kaila, Hao, Zhang, Wei and Yao.