Erianin是一种具有治疗潜力的植物雌激素，是Dendrobium huoshanense的主要活性成分之一。Erianin具有多种药理学作用，包括抗肿瘤、抗炎、抗糖尿病性视网膜病变、抗银屑病和抗菌等作用。尤其对于erianin的抗肿瘤作用，其潜在的分子机制已经部分阐明。事实上，erianin的许多药理作用是复杂且相互关联的，主要包括ERK1/2、PI3K/Akt、JAK2/STAT3、HIF-1α/PD-L1、PPT1/mTOR、JNK/c-Jun和p38 MAPK信号途径等。然而，由于erianin的水溶性差和生物利用度低，严重影响和限制了其进一步开发和应用。因此，进一步探索更广泛的药理作用和机制、澄清药代动力学以及合成erianin衍生物是非常有意义和有价值的。综上所述，本文对erianin的药理作用及其机制、药代动力学和衍生物研究进行了综述，以此为erianin的开发和应用提供参考。 © 2023 Li, Zhang, Lai, Liang, Huang, Zhao, Xie and Peng.

Erianin, a phytoestrogen with therapeutic potential, is one of the major active components of Dendrobll caulis. Erianin has a variety of pharmacological effects, such as anti-tumor, anti-inflammatory, anti-diabetic retinopathy, anti-psoriasis, and antibacterial effects. Especially, in regard to the anti-tumor effect of erianin, the underlying molecular mechanism has been partly clarified. In fact, the numerous pharmacological actions of erianin are complex and interrelated, mainly including ERK1/2, PI3K/Akt, JAK2/STAT3, HIF-1α/PD-L1, PPT1/mTOR, JNK/c-Jun, and p38 MAPK signal pathway. However, on account of the poor water solubility and the low bioavailability of erianin, greatly affected and limited its further development and application. And it is worthwhile and meaningful to explore more extensive pharmacological effects and mechanisms, clarify pharmacokinetics, and synthesize the derivatives of erianin. Conclusively, in this paper, the pharmacological effects of erianin and its mechanism, pharmacokinetics, and derivatives studies were reviewed, in order to provide a reference for the development and application of erianin.Copyright © 2023 Li, Zhang, Lai, Liang, Huang, Zhao, Xie and Peng.