尽管先前的报告将接触绝缘材料与间皮瘤和慢性呼吸系统疾病的风险增加联系在一起，但缺乏评估其与冠状动脉疾病（CAD）风险之间关系的研究。我们旨在评估接触绝缘材料与绝缘工人CAD 10年风险之间的关系。在该横断面研究中，我们招募了来自阿尔伯塔省埃德蒙顿地方110号加热和保温绝缘工人工会的643名年满18岁的成年绝缘工人。我们获得了人口统计学信息、个人和家族病史以及工作接触史，包括对绝缘材料的接触时间（年）和类型。我们还进行了包括Framingham风险评分（FRS）在内的临床分析。在所有绝缘工人中，男性占89％（平均年龄±标准差：47±12岁），27％有父母患有心脏疾病的病史，22％患有合并慢性呼吸系统疾病。总共有53％的人报告有过接触石棉，而分别有61％、82％和94％的人报告有过接触陶瓷纤维、玻璃纤维和矿物纤维。在单因素接触多变量回归模型中，经验、婚姻状况和体重指数（BMI）校正后，发现石棉与更高的FRS相关（β：1.004，95％CI：0.003-2.00）。这种关联在多因素接触模型中保持一致，并且在患有合并慢性呼吸系统疾病的绝缘工人中，石棉接触与FRS之间的关联更为显著。我们的研究证明，除了癌症和慢性呼吸系统疾病外，石棉接触还可能对心脏产生影响，因此有必要进行系统监测以保护工人免受这些材料的不良影响。版权所有 © 2023 Moitra, Tabrizi, Khadour, Henderson, Melenka and Lacy.

Although previous reports link exposure to insulating materials with an increased risk of mesothelioma and chronic respiratory diseases, studies evaluating their associations with the risk of coronary artery diseases (CAD) are lacking.We aimed at evaluating the associations between exposure to insulating materials and the 10-year risk of CAD among insulators.In this cross-sectional study, we recruited 643 adults (≥18 years), full-time insulators from the Local 110 Heat and Frost Insulators and Allied Workers Union in Edmonton, Alberta. We obtained demographic information, personal and family history, and job-exposure history, including experience (years) and types of exposure to insulating materials. Clinical profiling including Framingham risk scores (FRS) was assessed.Of all insulators, 89% were men (mean ± SD age: 47 ± 12 years), 27% had a parental history of cardiac diseases, and 22% had a comorbid chronic respiratory disease. In total, 53% reported exposure to asbestos, while 61, 82, and 94% reported exposure to ceramic fibers, fiberglass, and mineral fibers, respectively. In single-exposure multivariable regression models adjusted for experience, marital status, and body mass index (BMI), asbestos was found to be associated with higher FRS (β: 1.004; 95%CI: 0.003-2.00). The association remained consistent in multi-exposure models and a higher association was found between asbestos exposure and FRS among insulators with comorbid chronic respiratory disease.Our study demonstrates that apart from cancer and chronic respiratory diseases, asbestos exposure may also have a cardiac effect, thus warranting the need for systematic surveillance to protect workers from the adverse effects of these materials.Copyright © 2023 Moitra, Tabrizi, Khadour, Henderson, Melenka and Lacy.