DNA折纸是一种先进的DNA自组装技术，它通过互补碱基配对原理整齐地折叠DNA链并创建特定结构。这些创新的DNA折纸纳米结构提供了许多好处，包括生物毒性较低、稳定性增强和适应性较强，使其成为携带抗肿瘤药物的极佳选择。此外，它们可以通过提供精确、靶向、多功能的药物传递系统，显着减少副作用并改善治疗成功率。本综述研究DNA折纸的原理和设计策略，提供有关该技术在抗肿瘤药物传递领域最新研究成果和发展趋势的宝贵见解。此外，我们还回顾了DNA折纸在癌症治疗中的关键功能和主要优势，其中一些方法还涉及DNA四面体的相关方面，旨在提供新颖的想法和有效的解决方案来应对癌症治疗中的药物传递挑战。版权所有© 2023 张，田，王，王，刘，龙和姜。

DNA origami is a cutting-edge DNA self-assembly technique that neatly folds DNA strands and creates specific structures based on the complementary base pairing principle. These innovative DNA origami nanostructures provide numerous benefits, including lower biotoxicity, increased stability, and superior adaptability, making them an excellent choice for transporting anti-tumor agents. Furthermore, they can considerably reduce side effects and improve therapy success by offering precise, targeted, and multifunctional drug delivery system. This comprehensive review looks into the principles and design strategies of DNA origami, providing valuable insights into this technology's latest research achievements and development trends in the field of anti-tumor drug delivery. Additionally, we review the key function and major benefits of DNA origami in cancer treatment, some of these approaches also involve aspects related to DNA tetrahedra, aiming to provide novel ideas and effective solutions to address drug delivery challenges in cancer therapy.Copyright © 2023 Zhang, Tian, Wang, Wang, Liu, Long and Jiang.