准确定位和高效治疗疾病的多功能纳米平台具有吸引力，但面临巨大挑战。通过不同功能性纳米颗粒（NPs）的物理组合，治疗性诊断试剂已被证明是有效的。然而，复杂的生物环境常常导致每种试剂的不明确命运，无法同时保持成像和治疗成分的行为方式。在这里，我们构建了"集成"治疗性NPs，即掺杂Gd的CuWO4（CWG），其具有强烈的近红外吸收（808 nm），是报道中CuWO4的吸收峰位于生物透明窗口的最长吸收峰。少量的Gd掺杂不仅赋予了它们杰出的磁共振成像能力（r1=12.01mM-1s-1），而且同时对基质离子（Cu）的价态产生了重要影响，这一点通过理论计算结果得到了证明。Cu的电荷分布偏移将有助于⚫OH的生成，有利于化学动力学疗法（CDT）。此外，CWG NPs展示了卓越的光声显像（PA）和计算机断层扫描（CT）成像能力（S=10.33HU mM-1）。这样的集成治疗性为多模式成像（MRI/CT/PA）引导的协同疗法（PTT/CDT）提供了一个全能单纳米颗粒的范例。版权所有，保留所有权利。

Accurate location and efficient treatment of diseases by multifunctional nanoplatforms is appealing but faces great challenges. Theranostic agents through the physical combination of different functional nanoparticles (NPs) have demonstrated to be effective. Yet, the complicated biological environment often leads to ambiguous fates of each agent, which fails to keep the behaviors of imaging and therapeutic components in a simultaneous manner. Herein, we have constructed "integrated" theranostic NPs, Gd-doped CuWO4 (CWG) with strong near-infrared (808 nm) absorption, the longest absorption peak of reported CuWO4 , located in biological transparent window. The single doping of trace amount of Gd not only endowed them with a distinguished magnetic resonance imaging (MRI) capability (r1 = 12.01 mM-1 s-1 ), but also concurrently imposed great effect on the valence states of matrix ion (Cu), as evidenced by theoretical calculation results. The charge distribution shift of Cu would facilitate ⚫OH generation, beneficial for chemodynamic therapy (CDT). Moreover, CWG NPs displayed remarkable photoacoustic (PA) and computed tomography (CT) imaging capabilities (S = 10.33 HU mM-1 ). Such integrated theranostics afforded a paradigm for multimodal imaging (MRI/CT/PA) guided synergistic therapy (PTT/CDT) with all-in-one single nanoparticle. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.