结直肠癌（CRC）是全球最常见的恶性肿瘤之一，也是癌症相关死亡的第三大原因。长链非编码RNA（lncRNA）是各种生理过程的关键调节因子，并在广泛的病理生理情况（如CRC）中发生异常表达。研究表明，lncRNA的异常表达明显调节CRC中p53基因的表达水平，从而激活多个下游途径。p53被认为是一个关键的肿瘤抑制基因，它在细胞应激反应中促进细胞周期阻滞、DNA修复、衰老或凋亡。p53在CRC以及各种类型的人类恶性肿瘤中也发生突变。因此，lncRNA以多种方式与p53信号转导通路相互作用，从而显著影响与CRC相关的过程。本文综述了在控制CRC的致癌、肿瘤进展和治疗耐药性中，lncRNA与p53通路之间的相互作用的当前研究进展。对CRC致癌机制的更深入了解可能对CRC的预防和治疗以及更多的研究具有重要意义。版权所有 © 2023 Elsevier GmbH。保留所有权利。

Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide and the third leading cause of cancer-related fatalities. Long non-coding RNAs (lncRNAs) are key regulators of diverse physiological processes and are dysregulated in a wide range of pathophysiological circumstances such as CRC. Studies revealed that aberrant expressions of lncRNAs clearly modulate the expression level of p53 gene in CRC, thereby transactivating multiple downstream pathways. P53 is regarded as a crucial tumor suppressor gene which promotes cell-cycle arrest, DNA repair, senescence or apoptosis in response to cellular stresses. P53 is also mutated in CRC as well as various types of human malignancies. Therefore, lncRNAs interact with the p53 signaling pathway in numerus ways and significantly influence CRC-related processes. The current findings in the investigation of the crosstalk between lncRNAs and the P53 pathway in controlling CRC carcinogenesis, tumor progression, and therapeutic resistance are summarized in the this review. A deeper knowledge of CRC carcinogenesis may also have implications in CRC prevention and treatment through more research.Copyright © 2023 Elsevier GmbH. All rights reserved.