本研究旨在证明游泳运动结合水飞蓟素和维生素C补充能够改善老年高脂饮食诱导的肝损伤大鼠的肝炎症、氧化应激和肝组织病理学。随机将40只老年雄性Wistar大鼠分配到五个组（每组n = 8）：正常饮食组（对照组）、高脂饮食组（HFD组）、HFD结合水飞蓟素和维生素C补充组（HFD + Sup组）、HFD结合游泳运动组（HFD + Exe组）和HFD结合水飞蓟素、维生素C补充和游泳运动组（HFD + Sup + Exe组）。HFD组的非酒精性脂肪肝模型持续诱导6周。在HFD饮食养育6周后，为期8周的补充灌胃日常并与HFD一同给予大鼠进行干预。此外，运动组的大鼠在同一时期进行每周5次的游泳锻炼。游泳锻炼和补充物结合使得肝炎症生物标志物肿瘤坏死因子-α和白介素-1β显著下降，同时增加总抗氧化能力和过氧化物酶体增生物激活受体α（P<0.05）。在老年高脂饮食引起的肝损伤大鼠中，运动和水飞蓟素和维生素C补充的结合有效减少了氧化应激、肝炎症、脂肪积累，并调节了肝酶。版权所有© 2023 Elsevier Inc. 保留所有权利。

The aim of this study was to demonstrate that swimming exercise combined with silymarin and vitamin C supplementation improves hepatic inflammation, oxidative stress, and liver histopathology in elderly rats with high-fat diet-induced liver damage.Forty elderly male Wistar rats were randomly assigned to five groups (n = 8 in each): a normal diet (control), a high-fat diet (HFD), HFD + silymarin and vitamin C supplementation (HFD+Sup), HFD + swimming exercise (HFD+Exe), and HFD+Sup+Exe group (HFD+Sup+Exe). The non-alcoholic fatty liver model was induced for 6 wk in the HFD groups. After 6 wk of consuming an HFD, a daily supplemental gavage was administered to rats as an intervention along with HFD in the supplement groups for 8 wk. Moreover, rats in the exercise groups were subjected to swimming exercise training 5 d/wk for the same period.The combination of swimming training and supplementation caused significant decreases in liver inflammatory biomarkers tumor necrosis factor-α and interleukin-1β while increasing total antioxidant capacity and peroxisome proliferator-activated receptor α (P < 0.05).In elderly rats with liver injury caused by an HFD, the combination of exercise and silymarin with vitamin C supplementation effectively reduced oxidative stress, liver inflammation, fat accumulation, and regulated liver enzymes.Copyright © 2023 Elsevier Inc. All rights reserved.