向Th2免疫环境演变有进展的长期皮肤T细胞淋巴瘤（CTCL）患者，表现出进行性免疫抑制。疾病相关的免疫抑制以及某些CTCL治疗的免疫抑制性特征的结合，增加了感染和肿瘤疾病的风险，有时导致致命后果。为了前瞻性研究CTCL患者死亡的原因，在一所高等学府皮肤癌中心进行。纳入了2008年至2020年期间所有死亡的CTCL患者。死亡原因被分类为与CTCL直接相关、间接相关或无关。研究期间有31名（13名女性/18名男性）CTCL患者去世（平均年龄：75.2岁，诊断与死亡之间的平均延迟时间：3.2年（最小：1年，最大：12年），58.1%的死因被归类为间接相关（感染），12.9%直接相关（爆发转化），22.5%无关，6.5%原因不明。51.6%去世的MF患者患有早期疾病（IA-IIA）或处于缓解期。45.2%的死亡患者患有晚期MF（IIB-IVB）。感染者的CRP水平平均增高，而爆发病例中LDH水平增高。高等中心有望管理更大比例的晚期CTCL患者。由于感染占CTCL患者死亡原因的50%以上，应特别关注预防性措施，如抗感染疫苗接种。定期监测CRP和LDH水平对于MF患者的随访可能是有帮助的，分别与感染和爆发症有关。巴塞尔S. Karger AG。

The advancing evolution towards a Th2 immune environment confers a progressive immunosuppression in patients with longstanding cutaneous T-cell lymphoma (CTCL). The conjunction of the disease-related immunosuppression as well as the immunosuppressive character of some CTCL treatments increase the risk of infectious and neoplastic diseases, sometimes with fatal outcomes.To prospectively study the causes of death in a cohort of CTCL patients, in a tertiary university skin cancer center.All CTCL patients who died between 2008 to 2020 were included. The cause of the death was classified as directly or indirectly related or unrelated to CTCL.Over the study period 31 (13F/18M) patients with CTCL died (mean age: 75.2 years, mean delay between diagnosis and death: 3.2 years (min: 1, max: 12 years), 58.1% of death causes were classified as indirect (infection), 12.9% directly related (blastic transformation), 22.5% unrelated and 6.5% of unknown cause. 51.6% of MF patients who died had early-stage disease (IA-IIA) or were on remission. 45.2% of dead patients had advanced-stage MF (IIB-IVB). Mean CRP level is increased in patients who died from infection whereas LDH level increased in patients with blastosis. A tertiary center is expected to manage of a higher proportion of CTCL patients with advanced-stage disease.As infection represented more than 50% of the causes of death in CTCL patients, particular attention should be given to preventive measures such as anti-infective vaccination. Regular surveillance of CRP and LDH levels could be helpful for follow-up of MF patients, respectively with regards to infection and blastosis.S. Karger AG, Basel.