钛碳化物MXene量子点修饰的羟基磷灰石中空微球作为pH/近红外双响应药物载体。
Titanium Carbide MXene Quantum Dots-Modified Hydroxyapatite Hollow Microspheres as pH/Near-Infrared Dual-Response Drug Carriers.
发表日期：2023 Aug 23
作者：
Miaomiao Liu, Xiaosen Pan, Yuanjing Gan, Meng Gao, Xinran Li, Zhen Liu, Xiaojun Ma, Mengru Geng, Xiangqi Meng, Ning Ma, Jie Li
来源：
Cellular & Molecular Immunology
摘要：
钛碳化物MXene量子点（MQDs）具有固有的调控性能和对癌细胞的选择性毒性。本研究选取MQDs来修饰羟基磷灰石（HA）微球，制备了具有可控形状和尺寸的MXene量子点修饰的羟基磷灰石（MQDs-HA）空心微球，作为骨药物载体。结果表明，所制备的MQDs-HA空心微球具有较大的BET比表面积（231.2 m2/g），良好的荧光性能和低毒性。此外，MQDs-HA显示出较为温和的储存释放行为，并对pH值和近红外（NIR）具有良好的响应性。因此，MQDs-HA空心微球在药物传递和光热治疗领域具有广阔的应用前景。
Titanium carbide MXene quantum dots (MQDs) possess intrinsic regulatory properties and selective toxicity to cancer cells. Here, MDQs were selected for the modification of hydroxyapatite (HA) microspheres, and MXene quantum dots-modified hydroxyapatite (MQDs-HA) hollow microspheres with controllable shapes and sizes were prepared as bone drug carriers. The results show that the prepared MQDs-HA hollow microspheres had a large BET surface area (231.2 m2/g), good fluorescence, and low toxicity. In addition, MQDs-HA showed a mild storage-release behavior and good responsiveness of pH and near-infrared (NIR). Thus, the MQDs-HA hollow microspheres have broad application prospects in the field of drug delivery and photothermal therapy.