近二十年来，金纳米笼 (AuNCs) 作为临床医学中的生物材料被发明和开发，并展现出巨大的应用潜力。AuNCs 具有孔壁和空腔内部的特征结构，且体积紧凑。这使得它们能够运输生物分子或药物，具有光热效应的优势，可进一步摧毁细菌或肿瘤，并调控药物的释放。此外，利用细胞膜展示技术可以拓宽其生物活性和应用范围。AuNCs 在抗菌活性、炎症调节和组织再生方面显示出巨大的潜力，这些特性在牙周炎和种植体周围炎的治疗中是必需的。因此，本文综述了 AuNCs 的合成、特性、表面修饰和临床应用，旨在为牙周或种植体应用中基于 AuNCs 的智能材料的设计和制造提供参考。© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Gold nanocages (AuNCs) have been invented and developed over two decades as biomaterial in clinical medicine with great application potential. AuNCs have a characteristic structure of porous walls with hollow interior and a compact size. This makes it possible for them to transport biomolecules or drugs with the advantages of their photothermal effects that could help further destroy germs or tumors while also regulating the release of drugs inside. Furthermore, their bioactivity and application can be broadened by using cell-membrane display technology. AuNCs have shown tremendous potential in antibacterial activity, inflammation modulation, and tissue regeneration, which is required in periodontitis and peri-implantitis treatment. Thus, this article provides an overview of AuNCs synthesis, characteristics, surface modifications, and clinical applications, aiming to serve as a reference for the design and fabrication of AuNCs-based smart materials for periodontal or peri-implant application.© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.