目前尚不清楚童年癌症史是否会改变一般人群中存在的心血管危险因素（CVRFs）的差异。我们旨在确定童年癌症幸存者种族/民族间CVRFs的差异是否与一般人群相似。童年癌症幸存者研究（CCSS）是一个回顾性队列研究，追踪24,084名于1970年至1999年间诊断的5年存活者。多变量分段指数回归估计了种族/民族间高血压、高脂血症、糖尿病、肥胖和≥2个CVRFs的发病率比率（IRR）。CCSS同胞队列和国家健康和营养调查（NHANES）队列用于比较同种族/同民族差异的社会经济调整IRR。非西班牙裔黑人（NHB）（n = 1,092）和西班牙裔（n = 1,405）幸存者与非西班牙裔白人（NHW）（n = 13,960）幸存者相比，报告40岁时的糖尿病累积发病率较高（分别为8.4％、9.7％和5.1％）；肥胖（分别为47.2％、48.9％和30.2％）；多重CVRF（分别为17.7％、16.6％和12.3％）；对于NHB幸存者，高血压（分别为19.5％、13.6％和14.3％）（P < 0.001）。在控制社会经济和治疗因素的情况下，与NHW幸存者相比，NHB幸存者的高血压IRR增加（IRR：1.4；95％CI：1.1-1.8），肥胖IRR增加（IRR：1.7；95％CI：1.4-2.1），多重CVRF IRR增加（IRR：1.6；95％CI：1.2-2.1）。西班牙裔幸存者的糖尿病IRR增加（IRR：1.8；95％CI：1.2-2.6）和肥胖IRR增加（IRR：1.4；95％CI：1.2-1.7）。CVRF差异的IRR模式在CCSS同胞和国家健康和营养调查队列中相似。与NHW幸存者相比，NHB和西班牙裔幸存者的CVRF负担较高，与一般人群相似。在这个高危人群中，促进心血管健康公平至关重要。© 2023 作者。

It is unknown whether a history of childhood cancer modifies the established disparities in cardiovascular risk factors (CVRFs) observed in the general population.We sought to determine if disparities in CVRFs by race/ethnicity are similar among childhood cancer survivors compared with the general population.The Childhood Cancer Survivor Study (CCSS) is a retrospective cohort with a longitudinal follow-up of 24,084 5-year survivors diagnosed between 1970 and 1999. Multivariable piecewise exponential regression estimated incidence rate ratios (IRRs) for hypertension, hyperlipidemia, diabetes, obesity, and ≥2 CVRFs by race/ethnicity. The CCSS sibling cohort and the National Health and Nutrition Examination Survey cohort were used to compare the sociodemographic-adjusted IRRs for same-race/same-ethnicity disparities.Non-Hispanic Black (NHB) (n = 1,092) and Hispanic (n = 1,405) survivors compared with non-Hispanic White (NHW) (n = 13,960) survivors reported a higher cumulative incidence of diabetes (8.4%, 9.7%, and 5.1%, respectively); obesity (47.2%, 48.9%, and 30.2%, respectively); multiple CVRFs (17.7%, 16.6%, and 12.3%, respectively); and, for NHB survivors, hypertension (19.5%, 13.6%, and 14.3%, respectively) by 40 years of age (P < 0.001). Controlling for sociodemographic and treatment factors compared with NHW survivors, IRRs for NHB were increased for hypertension (IRR: 1.4; 95% CI: 1.1-1.8), obesity (IRR: 1.7; 95% CI: 1.4-2.1), and multiple CVRFs (IRR: 1.6; 95% CI: 1.2-2.1). IRRs for Hispanic survivors were increased for diabetes (IRR: 1.8; 95% CI: 1.2-2.6) and obesity (IRR: 1.4; 95% CI: 1.2-1.7). The pattern of IRRs for CVRF differences was similar among CCSS sibling and National Health and Nutrition Examination Survey cohorts.The higher burden of CVRFs among NHB and Hispanic survivors compared with NHW survivors was similar to the general population. The promotion of cardiovascular health equity is critical in this high-risk population.© 2023 The Authors.