垂体是我们内分泌系统的中心。其细胞产生特定激素，指导多个重要的生理过程，如体格发育、生育能力和应激反应。垂体还含有一群干细胞，其表型和功能依然神秘。需要合适的研究模型来推进我们对垂体（干细胞）生物学的认识。在过去十年里，已经建立了三维器官样模型，其中既有来自垂体干细胞的模型，又有来自多能干细胞的模型，涵盖了健康和疾病条件。在这里，我们总结了与垂体相关的器官样模型的最新进展，并讨论了利用这些强大的体外研究和转化工具研究垂体发育、生物学和疾病的应用。版权所有©2023 Laporte 和 Vankelecom。

The pituitary gland represents the hub of our endocrine system. Its cells produce specific hormones that direct multiple vital physiological processes such as body growth, fertility, and stress. The gland also contains a population of stem cells which are still enigmatic in phenotype and function. Appropriate research models are needed to advance our knowledge on pituitary (stem cell) biology. Over the last decade, 3D organoid models have been established, either derived from the pituitary stem cells or from pluripotent stem cells, covering both healthy and diseased conditions. Here, we summarize the state-of-the-art of pituitary-allied organoid models and discuss applications of these powerful in vitro research and translational tools to study pituitary development, biology, and disease.Copyright © 2023 Laporte and Vankelecom.