脂肪组织（AT）是一个复杂的代谢器官，由异质细胞群体组成，对系统代谢调控和维持代谢稳态产生广泛影响。各种与肥胖相关的并发症与AT功能失调的发展有关。作为细胞间信息的重要传递者，细胞外囊泡（EVs）最近被认定为调控多种生理功能的关键因素。本文概述了AT释放的细胞外囊泡（ADEVs）在代谢性和心血管疾病、癌症和神经疾病的稳态调控中的作用，通过在不同细胞之间传递脂类、蛋白质和核酸。此外，还讨论了源于AT的ADEVs的不同来源，如脂肪细胞、AT巨噬细胞、AT来源的干细胞和AT来源的间充质干细胞。本综述可为潜在应用ADEVs治疗代谢综合征、心血管疾病、癌症和神经疾病提供有价值的信息。

Adipose tissue (AT) is a complicated metabolic organ consisting of a heterogeneous population of cells that exert wide‑ranging effects on the regulation of systemic metabolism and in maintaining metabolic homeostasis. Various obesity‑related complications are associated with the development of dysfunctional AT. As an essential transmitter of intercellular information, extracellular vesicles (EVs) have recently been recognized as crucial in regulating multiple physiological functions. AT‑derived extracellular vesicles (ADEVs) have been shown to facilitate cellular communication both inside and between ATs and other peripheral organs. Here, the role of EVs released from ATs in the homeostasis of metabolic and cardiovascular diseases, cancer, and neurological disorders by delivering lipids, proteins, and nucleic acids between different cells is summarized. Furthermore, the differences in the sources of ADEVs, such as adipocytes, AT macrophages, AT‑derived stem cells, and AT‑derived mesenchymal stem cells, are also discussed. This review may provide valuable information for the potential application of ADEVs in metabolic syndrome, cardiovascular diseases, cancer, and neurological disorders.