哺乳动物雷帕霉素靶蛋白复合物1综合症（Tors）典型意味着一种由高活性的mTORC1驱动的详尽结合的疾病实体，其中包括肥胖、2型糖尿病高血糖、糖尿病血脂异常、糖尿病心肌病、糖尿病肾病、糖尿病外周神经病变、高血压、动脉粥样硬化性心血管疾病、非酒精性脂肪肝、某些癌症、神经退行性疾病、多囊卵巢综合征、银屑病等。Tors典型可以解释标准治疗2型糖尿病（T2D）对T2D和非T2D患者中的Tors糖尿病相关和非糖尿病相关疾病的糖代谢减轻疗效。Tors典型可以为Tors疾病提供新颖治疗方法。© 2023 The Authors. Diabetes/Metabolism Research and Reviews刊登John Wiley & Sons Ltd发表。

The mammalian target of rapamycin complex 1 syndrome (Tors), paradigm implies an exhaustive cohesive disease entity driven by a hyperactive mTORC1, and which includes obesity, type 2 diabetic hyperglycemia, diabetic dyslipidemia, diabetic cardiomyopathy, diabetic nephropathy, diabetic peripheral neuropathy, hypertension, atherosclerotic cardiovascular disease, non-alcoholic fatty liver disease, some cancers, neurodegeneration, polycystic ovary syndrome, psoriasis and other. The TorS paradigm may account for the efficacy of standard-of-care treatments of type 2 diabetes (T2D) in alleviating the glycaemic and non-glycaemic diseases of TorS in T2D and non-T2D patients. The TorS paradigm may generate novel treatments for TorS diseases.© 2023 The Authors. Diabetes/Metabolism Research and Reviews published by John Wiley & Sons Ltd.