在恶性肿瘤中，包括胶质母细胞瘤（GBM）在内，代谢基因的再编程和随后的代谢表型变化广泛发生。FOXM1是一个强有力的转录因子，通过调控许多基因的表达起到致癌作用。作为一个含有SET结构域的蛋白质，SET7是一个蛋白质赖氨酸甲基转移酶，可以对组蛋白蛋白质和其他蛋白质进行单甲基化修饰。组蛋白的表观遗传修饰通过对DNA的启动子进行表观遗传修饰并干预肿瘤发展来调节基因表达。FASN的活化增加了新生脂肪酸（FA）合成，这是癌细胞的一个标志性特征。在这里，我们报告了FOXM1可能直接促进SET7的转录，并激活SET7-H3K4me1-FASN轴，从而维持新生FA合成。© 2023. 细胞死亡和分化协会（ADMC）。

Reprogramming of metabolic genes and subsequent alterations in metabolic phenotypes occur widely in malignant tumours, including glioblastoma (GBM). FOXM1 is a potent transcription factor that plays an oncogenic role by regulating the expression of many genes. As a SET domain containing protein, SET7 is a protein lysine methyltransferase which monomethylates histone proteins and other proteins. The epigenetic modification of histones regulates gene expressions by epigenetically modifying promoters of DNAs and inter vening in tumor development. Activation of FASN increased de novo fatty acid (FA) synthesis, a hallmark of cancer cells. Here, we report that FOXM1 may directly promote the transcription of SET7 and activate SET7-H3K4me1-FASN axis, which results in the maintenance of de novo FA synthesis.© 2023. Cell Death Differentiation Association (ADMC).