口腔功能减退包括咀嚼、吞咽、发音、口腔卫生和口干。然而，目前尚不清楚口腔功能减退和每个个体条件是否对整体健康产生不利影响。本研究旨在探讨口腔功能减退与整体健康之间的关联，包括身体、心理和社交维度。根据2016年日本老年牙科学会提出的标准，诊断口腔功能减退包括7个口腔功能条件，其中至少有3个条件存在时方可诊断为口腔功能减退。选择符合以下PI(E)CO标准的研究进行审查：P（人群），成年和老年人群；I/E（介入/暴露），考虑整体和个体的7个口腔功能条件；C（对照组），没有口腔功能减退；O（结果），包括身体、心理和社交维度的整体健康状况。通过PubMed、Scopus和Cochrane数据库对英文文章进行电子检索，时间范围为2016年1月至2023年6月。评估所纳入研究的质量和偏倚风险使用修正后的Newcastle-Ottawa量表。对整体结果和考虑整体和个体口腔功能条件的口腔功能减退进行定性分析。最终合成了十项研究，其中一项是前瞻性队列研究，一项是病例对照研究，其余为横断面研究。所有纳入研究均具有较高的质量。整体健康结果主要表现为虚弱、肌无力和营养不良，而轻度认知障碍、社交退缩和胃癌预后仅在其中一项纳入研究中得到确认。口腔功能减退与整体健康之间的关联程度大于考虑个体条件时的关联程度。健康结果主要与咀嚼和吞咽相关，而与口腔卫生和口干的关联报道较少。本综述发现口腔功能减退与整体健康不良有关联。但是，对个体身体、心理和社交维度的具体影响尚不明确。需要进一步的前瞻性研究来阐明口腔健康与整体健康之间的因果关系。© 2023. BioMed Central Ltd., part of Springer Nature.

Oral hypofunction comprises 7 oral function conditions, including mastication, swallowing, pronouncing, oral hygiene, and oral dryness. However, it remains unresolved whether having oral hypofunction and each individual condition adversely affect general health. This study aimed to investigate the association between oral hypofunction and general health, encompassing physical, psychological, and social dimensions.Oral hypofunction was diagnosed following the criteria proposed by the 2016 Japan Society of Gerodontology, comprising 7 oral function conditions. Oral hypofunction was diagnosed when at least 3 conditions presented. The selected studies eligible for reviewing were based on the PI(E)CO criteria: P (population), adult and older adults; I/E (intervention/exposure), having oral hypofunction by considering overall and individual 7 oral function conditions; C (comparator), not having oral hypofunction; O (outcome), the general health status, encompassing physical, psychological, and social dimensions. Electronic search limited to English articles was performed through PubMed, Scopus, and Cochrane Database of Systematic Reviews databases from January 2016 to June 2023. The included studies were assessed for quaility and risk of bias using the modified Newcastle-Ottawa scale. Qualitative analyses were performed on the general outcome, and having oral hypofunction considering overall and individual oral function conditions.Ten studies were included in the final syntheses. One was a prospective cohort, one was a case-control, and the others were cross-sectional studies. All included studies were high quality. General health outcomes were mostly frailty, sarcopenia, and malnutrition, whereas mild cognitive impairment,social withdrawal, and gastric cancer prognosis were identified in one of the included studies. The association between general health and having oral hypofunction was stronger than when considering an individual condition. The health outcomes were predominantly associated with mastication and swallowing, whereas their relationships with oral hygiene and dryness were less likely to be reported.The present review found an association between the presence of oral hypofunction and impaired general health. However, the specific impact on individual physical, psychological, and social dimensions cannot be distinctly delineated. Further prospective studies are required to clarify the causal-effect relationship between oral and general health.© 2023. BioMed Central Ltd., part of Springer Nature.