建立起源于高级浆液性卵巢癌患者的癌细胞系。
Establishment of cancer cell line originating from a patient with high-grade serous ovarian carcinoma.
发表日期：2023 Sep
作者：
Nguyen Thuy Linh, Ngo Thu Hang, Bui Khac Cuong, Dang Thuy Linh, Nham Thi Phuong Linh, Do Nguyen-Van, Tran Ngoc Dzung, Can Van Mao, Dang Thanh Chung, Le Tri Chinh, Nguyen Phu Hung, Hoang Van Tong, Nguyen Linh Toan
来源：
BIOMEDICINE & PHARMACOTHERAPY
摘要：
卵巢癌是一种具有高发病率和死亡率的严重恶性肿瘤。我们从一名越南卵巢癌患者的肿瘤中分离并鉴定了一种高级别浆液性卵巢癌细胞系（M4）。在培养条件下，M4癌细胞系显示出良好的增殖和稳定性。在形态上，M4细胞呈多面形状，具有大的不规则核，高核质比，高核密度，并且表达CA125、p53和Ki67等癌症标记物，类似于肿瘤细胞的特征。我们成功地从一名越南卵巢癌患者中分离并鉴定了M4细胞系。© 2023年作者。
Ovarian cancer is a serious malignancy with high prevalence and mortality.We isolated and characterized an ovarian high-grade serous cancer cell line (M4) from a tumor of a Vietnamese patient with ovarian carcinoma.The M4 cancer cell line showed good proliferation and stability in culture. Morphologically, the M4 cells showed similar characteristics to tumor cells such as a polyhedral shape, large irregular nuclei, high nuclear/cytoplasmic ratio, high nuclear density and expressing cancer markers like CA125, p53 and Ki67 markers.We have successfully isolated and characterized the M4 cell line from a Vietnamese patient with ovarian carcinoma.© 2023 The Authors.