二甲双胍是一种常规使用且低成本的通用药物。已经有人提出将二甲双胍作为二肽基肽酶-4（DPP4）表达的靶点，用于各种临床疾病。我们进行了分子对接和动力学建模的“体外”研究，探究二甲双胍和DPP4的潜在相互作用。此外，我们还进行了生物信息学研究，以突出DPP4表达和不同恶性肿瘤类型中的突变以及不同免疫细胞侵入肿瘤微环境的临床意义。我们相信本提案的研究结果对于理解二甲双胍通过靶向DPP4表达在恶性肿瘤中可能提供健康好处的机制具有重要意义。© 2023. 作者。

Metformin is a regularly prescribed and low-cost generic medication. Metformin has been proposed as a target for Dipeptidyl-peptidase 4 (DPP4) expression in various clinical disorders. We provide insilco investigations on molecular docking and dynamic modeling of metformin and DPP4 potential interactions. Moreover, we conducted bioinformatic studies to highlight the clinical significance of DPP4 expression and mutation in various types of malignancies, as well as the invasion of different immune cells into the tumor microenvironment. We believe the present proposal's findings have crucial implications for understanding how metformin may confer health advantages by targeting DPP4 expression in malignancies.© 2023. The Author(s).