为了研究英国2型糖尿病诊断年龄与全因死亡和特定原因死亡的相对和绝对风险之间的关联，本研究采用了来自临床实践研究数据库的初级保健数据，我们确定了108,061名新被诊断为2型糖尿病（16-50岁）的个体并匹配了829,946名没有2型糖尿病的个体。我们使用竞争风险生存分析估计了不同年龄诊断的全因死亡和特定原因死亡（癌症，心肾，其他[非癌症或心肾]），并对重要混杂因素进行了调整。相较于没有2型糖尿病的个体，2型糖尿病患者的死亡相对风险随着诊断年龄的增长而降低：16-27岁诊断年龄组全因死亡的危险比为4.32（95％置信区间3.35-5.58），而48-50岁诊断年龄组为1.53（95％置信区间1.46-1.60）。从增加的诊断年龄来看，癌症、心肾和非癌症或心肾死亡的相对风险也较小。无论诊断年龄如何，2型糖尿病患者的10年全因和特定原因死亡绝对风险都较高，但绝对差异很小。尽管与没有2型糖尿病的个体相比，2型糖尿病患者的相对风险在年龄较小时较高，但两组的10年各种死亡原因的绝对风险很小且相似。进一步的多年代研究可以帮助估计早发2型糖尿病患者的并发症和死亡的长期风险。© 2023美国糖尿病协会。

To examine the associations between age at type 2 diabetes diagnosis and the relative and absolute risk of all-cause and cause-specific mortality in England.In this cohort study using primary care data from the Clinical Practice Research Datalink, we identified 108,061 individuals with newly diagnosed type 2 diabetes (16-50 years of age), matched to 829,946 individuals without type 2 diabetes. We estimated all-cause and cause-specific mortality (cancer, cardiorenal, other [noncancer or cardiorenal]) by age at diagnosis, using competing-risk survival analyses adjusted for key confounders.Comparing individuals with versus without type 2 diabetes, the relative risk of death decreased with an older age at diagnosis: the hazard ratio for all-cause mortality was 4.32 (95% CI 3.35-5.58) in individuals diagnosed at ages 16-27 years compared with 1.53 (95% CI 1.46-1.60) at ages 48-50 years. Smaller relative risks by increasing age at diagnosis were also observed for cancer, cardiorenal, and noncancer or cardiorenal death. Irrespective of age at diagnosis, the 10-year absolute risk of all-cause and cause-specific mortality were higher in individuals with type 2 diabetes; yet, the absolute differences were small.Although the relative risk of death in individuals with versus without type 2 was higher at younger ages, the 10-year absolute risk of all investigated causes of death was small and similar in the two groups. Further multidecade studies could help estimate the long-term risk of complications and death in individuals with early-onset type 2 diabetes.© 2023 by the American Diabetes Association.