GRB2-关联的结合蛋白1 (GAB1) 是GAB/DOS家族的第一个pleckstrin homology (PH)结构域蛋白。在接受各种刺激后，GAB1从细胞质转移至细胞膜，在那里被一系列激酶磷酸化。这个事件招募了含有SH2结构域的蛋白，如SHP2，PI3K的p85亚基，CRK等，从而激活不同的信号通路，包括MAPK，PI3K/AKT和JNK。GAB1缺乏的胚胎在子宫内期死亡，表现出心脏，胎盘，肝脏，皮肤，肢体和膈肌肌细胞的发育异常。在癌症背景下已经发现了致癌突变。GAB1表达水平在多种肿瘤中受到破坏，患者中的高水平通常预示着多种癌症类型的恶化预后。本综述重点讨论GAB1对细胞转化的影响，特别是在增殖、逃避凋亡、转移和血管生成等与癌症相关的过程中的作用。GAB1还调节对抗肿瘤疗法的抗性/敏感性，使其成为未来抗癌策略中值得期待的靶点。

GRB2-associated binder 1 (GAB1) is the inaugural member of the GAB/DOS family of pleckstrin homology (PH) domain-containing proteins. Upon receiving various stimuli, GAB1 transitions from the cytoplasm to the membrane where it is phosphorylated by a range of kinases. This event recruits SH2 domain-containing proteins like SHP2, PI3K's p85 subunit, CRK, and others, thereby activating distinct signaling pathways, including MAPK, PI3K/AKT, and JNK. GAB1-deficient embryos succumb in utero, presenting with developmental abnormalities in the heart, placenta, liver, skin, limb, and diaphragm myocytes. Oncogenic mutations have been identified in the context of cancer. GAB1 expression levels are disrupted in various tumors, and elevated levels in patients often portend a worse prognosis in multiple cancer types. This review focuses on GAB1's influence on cellular transformation particularly in proliferation, evasion of apoptosis, metastasis, and angiogenesis-each of these processes being a cancer hallmark. GAB1 also modulates the resistance/sensitivity to antitumor therapies, making it a promising target for future anticancer strategies.