本研究的目的是调查上皮膜蛋白（EMP）1、2和3在肾上腺肿瘤中的表达，并探讨其更广泛的意义。共构建了132例肾上腺皮质肿瘤（ACN）（肾上腺皮质腺瘤115例和癌17例）以及189例嗜铬细胞瘤的组织微阵列。利用免疫组化染色鉴定EMP 1、2和3，并与临床病理参数进行比较。当与ACN相比较时，嗜铬细胞瘤中EMP 3的H-score（p < 0.001）较高，肾上腺皮质癌中EMP 1（p < 0.001）和EMP 3（p < 0.001）的H-score较高。在嗜铬细胞性瘤中，EMP 1的H-score较高（p = 0.018），GAPP评分≥3。在单因素分析中，ACN中EMP 1和EMP 3的高表达与总生存期较短相关（p = 0.001）。在ACN和嗜铬细胞瘤之间发现EMP的表达差异。EMP与肾上腺皮质增生和嗜铬细胞瘤的恶性肿瘤生物学相关，提示EMP在肾上腺肿瘤中具有预后和/或预测因子的作用。

The purpose of this study is to investigate the expression of the epithelial membrane proteins (EMP) 1, 2, and 3 in adrenal gland neoplasm and to explore the broader implications of this. Tissue microarrays were constructed for 132 cases of adrenal cortical neoplasms (ACN) (adrenal cortical adenoma (115 cases), and carcinoma (17 cases)) and 189 cases of pheochromocytoma. Immunohistochemical staining was performed to identify EMP 1, 2, and 3, and was compared with clinicopathological parameters. The H-score of EMP 3 (p < 0.001) was higher in pheochromocytoma when compared to that of ACN, and the H-score of EMP 1 (p < 0.001) and EMP 3 (p < 0.001) was higher in adrenal cortical carcinomas when compared to that of adrenal cortical adenomas. A higher EMP 1 H-score was observed in pheochromocytomas with a GAPP score ≥3 (p = 0.018). In univariate analysis, high levels of EMP 1 and EMP 3 expression in ACN were associated with shorter overall survival (p = 0.001). Differences were observed in the expression of EMPs between ACN and pheochromocytoma. EMPs are associated with malignant tumor biology in adrenal cortical neoplasm and pheochromocytoma, suggesting the role of a prognostic and/or predictive factor for EMPs in adrenal tumor.