报道了铜（II）与2,5-双（乙基硫代）-1,3,4-噻二唑（L1）和2,5-双（吡啶甲基硫代）-1,3,4-噻二唑（L2）形成的新配位化合物，其组成为Cu(L1)2Br2、Cu(L1)(C2N3)2、Cu(L2)Cl2和Cu(L2)Br2。通过元素分析、红外光谱（IR）、粉末X射线衍射（XRD）和静态磁化率进行了化合物的鉴定和研究。确定了铜（II）与L1的配位中心的晶体结构。通过扩展X射线吸收精细结构（EXAFS）光谱确定了Cu(L2)Cl2和Cu(L2)Br2配合物的配位中心的结构。磁化率测量揭示了研究化合物中各种不同的磁态，从几乎理想的顺磁体Cu(L1)2Br2到具有交替交换反铁磁链的Cu(L1)(C2N3)2，其中双双氰酸根离子提供了一个异常强烈的铜（II）离子之间的交换作用（J1/kB ≈ -23.5 K; J2/kB ≈ -20.2 K）。估计了铜（II）与L2配合物在人乳腺癌细胞系（MCF-7）和肝细胞癌细胞系（HepG2）上的细胞毒活性。

New coordination compounds of copper(II) with 2,5-bis(ethylthio)-1,3,4-thiadiazole (L1) and 2,5-bis(pyridylmethylthio)-1,3,4-thiadiazole (L2) with compositions Cu(L1)2Br2, Cu(L1)(C2N3)2, Cu(L2)Cl2, and Cu(L2)Br2 were prepared. The complexes were identified and studied by CHN analysis, infrared (IR) spectroscopy, powder X-Ray diffraction (XRD), and static magnetic susceptibility. The crystal structures of Cu(II) complexes with L1 were determined. The structures of the coordination core of complexes Cu(L2)Cl2 and Cu(L2)Br2 were determined by Extended X-ray absorption fine structure (EXAFS) spectroscopy. Magnetization measurements have revealed various magnetic states in the studied complexes, ranging from an almost ideal paramagnet in Cu(L1)2Br2 to alternating-exchange antiferromagnetic chains in Cu(L1)(C2N3)2, where double dicyanamide bridges provide an unusually strong exchange interaction (J1/kB ≈ -23.5 K; J2/kB ≈ -20.2 K) between Cu(II) ions. The cytotoxic activity of copper(II) complexes with L2 was estimated on the human cell lines of breast adenocarcinoma (MCF-7) and hepatocellular carcinoma (HepG2).