采用湿化学法，以磷酸二氢铵（（NH4)H2PO4）和硝酸钙（Ca(NO3)2·4H2O）作为钙离子和磷酸盐离子的来源，加入明胶，合成了具有锥形孔隙结构的羟基磷灰石-明胶微球，其骨生导性优于商业产品，如纤维蛋白胶和Osteoset®骨移植替代品。按照前研究中的方法进行紫杉醇（PTX）的载药，药物包封效率约为58%，明显低于多柔比星（DOX）载药的效率。鉴于PTX是疏水性的，而DOX是亲水性的，在本研究中调整了壳聚糖的处理顺序和溶剂的加入方式，最终将药物包封效率提高至94%。此外，PTX的释放持续时间超过六个月。MTT试验表明，药物释放对癌细胞的抑制效果在一周后达到40%以上，从而显示了PTX在药物载荷过程中不受影响地发挥其药用功能的能力。

Hydroxyapatite-gelatin microspheres with cone-like pores were synthesized via the wet-chemical method using ammonium dihydrogen phosphate ((NH4)H2PO4) and calcium nitrate (Ca(NO3)2·4H2O) as a source of calcium and phosphate ions with the addition of gelatin, which proved to be more osteoconductive than commercial products, such as fibrin glue and Osteoset® Bone Graft Substitute. Following the method of the previous study for loading paclitaxel (PTX), a drug entrapment efficiency of around 58% was achieved, which is much lower than that of the doxorubicin (DOX)-loaded one. Since PTX is hydrophobic while DOX is hydrophilic, the order of chitosan processing and addition of the solvent were tuned in this study, finally leading to an increase in drug entrapment efficiency of 94%. Additionally, the release duration of PTX exceeded six months. The MTT assay indicated that the effect of drug release on the suppression of cancer cells reached more than 40% after one week, thereby showcasing PTX's capacity to carry out its medicinal functions without being affected by the loading procedures.