(1) 背景：Riparin-A已被证明具有多种药理活性，如抗微生物调节剂、抗利什曼病、抗焦虑、抗炎、抗痛和抗氧化作用。尽管具有重要的生物活性效应，但由于其在水中的溶解度低，使其在生物体液中的溶解受到限制。因此，本研究的目的是基于Riparin-A和莱蓬石的纳米杂化体系，以获得更好的溶解特性并评估其细胞毒性潜力。(2) 方法：通过X射线粉末衍射、红外光谱和热分析突出了复合体系的形成。进行了溶解度、溶解度和细胞毒性研究；(3) 结果：在粘土存在下观察到Riparin-A的溶解度和水溶解速率的增加。杂化体系的衍射分析表明了Riparin-A的非晶化，热分析表明与粘土相互作用后Riparin-A的分解和熔化过程的减弱。此外，纳米体系在正常和肿瘤细胞株上没有显示出细胞毒性活性。(4) 结论：这些结果对于开发Riparin-A/莱蓬石纳米体系用于治疗目的具有前景，表明该生物活性化合物的给药途径和生物利用度的可能性增加。

(1) Background: Riparin-A presents several pharmacological activities already elucidated, such as antimicrobial modulator, antileishmania, anxiolytic, anti-inflammatory, antinociceptive, and antioxidant. Even with important bioactive effects, the applicability of Riparin-A is limited due to its low solubility in water, impairing its dissolution in biological fluids. Thus, the objective of this study was to develop a nanohybrid based on Riparin-A and Laponite to obtain a better dissolution profile and evaluate its cytotoxic potential. (2) Methods: The formation of a hybrid system was highlighted by X-ray powder diffraction, infrared spectroscopy, and thermal analysis. Solubility, dissolution, and cytotoxicity studies were performed; (3) Results: An increase in the solubility and aqueous dissolution rate of Riparin-A was observed in the presence of clay. Diffractometric analysis of the hybrid system suggests the amorphization of Riparin-A, and thermal analyses indicated attenuation of decomposition and melting of the Riparin-A after interaction with clay. Furthermore, the nanosystem did not exhibit cytotoxic activity on normal and tumorigenic lines. (4) Conclusions: These results are promising for the development of the Riparin-A/Laponite nanosystem for therapeutic purposes, suggesting an increase in the range of possible routes of administration and bioavailability of this bioactive compound.