本研究构建了pH响应型的碳纳米管修饰纳米药物传递体系（CNTs/Gel/Cp），采用明胶（Gel）修饰的碳纳米管（CNTs/Gel）负载顺铂（Cp），以精确缓慢释放药物，防止过早失活并保持有效浓度。当MCp:MCNTs/Gel = 1:1时，药物达到最高负载率和包封效率。为了实现持续释放效果，CNTs/Gel/Cp在pH 6.0环境中可以稳定缓慢释放药物。此外，CNTs/Gel/Cp以剂量相关方式表现出与顺铂相当的抗肿瘤性能。这些发现表明CNTs/Gel/Cp具有有效持续释放顺铂和良好的抗肿瘤效果，为改性碳纳米管（CNTs）作为新的药物传递系统的临床应用提供了理论和实验基础。

Cisplatin (Cp), a chemotherapeutic agent, interacts with purines on tumor DNA, causing tumor cell apoptosis. However, cisplatin has the characteristics of non-specific distribution and lack of selectivity, resulting in systemic toxicity. Moreover, it cannot maintain the drug's high concentration in the tumor-weak acid environment. These flaws of cisplatin restrict its use in clinical applications. Therefore, a pH-responsive carbon nanotube-modified nano-drug delivery system (CNTs/Gel/Cp) was constructed in this study using gelatin (Gel)-modified carbon nanotubes (CNTs/Gel) loaded with cisplatin to release drugs precisely and slowly, preventing premature inactivation and maintaining an effective concentration. When MCp:MCNTs/Gel = 1:1, the drug reaches the highest loading rate and entrapment efficiency. To achieve the sustained-release effect, CNTs/Gel/Cp can release the medicine steadily for a long time in a pH environment of 6.0. Additionally, CNTs/Gel/Cp display antitumor properties comparable to cisplatin in a manner that varies with the dosage administered. These findings indicate that CNTs/Gel/Cp have an effective, sustained release of cisplatin and a good antitumor effect, providing a theoretical and experimental basis for the clinical application of modified carbon nanotubes (CNTs) as a new drug delivery system.