CAR T细胞引发抗肿瘤免疫。
CAR T cells ignite antitumor immunity.
发表日期：2023 Aug 29
作者：
Darya Alizadeh, Christine E Brown
来源：
TRENDS IN IMMUNOLOGY
摘要：
通过抗原扩散扩大免疫反应仍然是癌症免疫治疗的“圣杯”。马等人的研究揭示了在小鼠中通过疫苗增强嵌合抗原受体（CAR-T）细胞可以促进内源性免疫，并通过干扰素(IFN)γ的关键机制诱导抗原扩散，从而消除异质抗原性实体瘤。版权所有©2023 Elsevier Ltd. 保留所有权利。
Broadening immune responses through antigen spreading remains the 'Holy Grail' of cancer immunotherapy. A study by Ma and colleagues reveals that vaccine boosting of chimeric antigen receptor (CAR)-T cells in mice promotes endogenous immunity and elicits antigen spread to eliminate antigenically heterogenous solid tumors through a mechanism crucially dependent on interferon (IFN)γ.Copyright © 2023 Elsevier Ltd. All rights reserved.