超增强子作为基因表达层次控制的顶层元素而进化。它们是控制干性、分化或适应性反应的信号通路的重要聚合器。许多表观遗传调控都集中在这些区域，因此在肿瘤发生过程中，各种变化可能导致其功能紊乱。超增强子日益成为维持癌细胞侵袭性的异常基因表达格局的关键驱动因素。在本综述中，我们将描述和讨论超增强子的结构、表观遗传调控以及影响其在癌症中功能的主要变化。版权所有 © 2023. Elsevier Inc. 发布。

Super-enhancers evolve as elements at the top of the hierarchical control of gene expression. They are important end-gatherers of signaling pathways that control stemness, differentiation or adaptive responses. Many epigenetic regulations focus on these regions, and not surprisingly, during the process of tumorigenesis, various alterations can account for their dysfunction. Super-enhancers are emerging as key drivers of the aberrant gene expression landscape that sustain the aggressiveness of cancer cells. In this review, we will describe and discuss about the structure of super-enhancers, their epigenetic regulation, and the major changes affecting their functionality in cancer.Copyright © 2023. Published by Elsevier Inc.