表面粘液剪切削弱了肿瘤细胞的力量。
Shearing of surface mucin saps tumor cell strength.
发表日期：2023 Sep 05
作者：
Liza J Greenberg, Deborah Fass
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES
摘要：
转膜黏液蛋白的异常表达促进肿瘤的进展，并干扰免疫和药理消除癌细胞的过程。在最近的一篇文章中，Pedram等人将一个减弱的细菌黏液特异性蛋白酶引导至HER2阳性肿瘤细胞，并观察到肿瘤生长速率下降和带有HER2阳性肿瘤的小鼠的存活时间延长。版权所有 © 2023 作者。由Elsevier Ltd.出版。保留所有权利。
Aberrant expression of transmembrane mucins promotes tumor progression and interferes with immunological and medicinal elimination of cancer cells. In a recent article, Pedram et al. directed an attenuated bacterial mucin-specific protease to HER2-positive tumor cells and observed decreased tumor growth rates and extended survival of mice bearing HER2-positive tumors.Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.