在细胞中，一种重要的蛋白质调控系统是泛素—蛋白酶体途径。底物在该途径中通过泛素连接酶系统（E1-E2-E3）进行修饰，这是一种动态的蛋白质双向修饰调节系统。去泛素化酶（DUBs）的任务是特异性水解泛素分子，从而逆向调控蛋白质降解，进而影响蛋白质功能。泛素特异性蛋白酶32（USP32）蛋白水平与细胞周期进程、增殖、迁移、侵袭及其他细胞生物学过程相关。它是泛素特异性蛋白酶家族的重要成员。据认为，控制泛素过程的独特酶USP32与多种癌症的发生和进展密切相关，包括小细胞肺癌、胃癌、乳腺癌、上皮性卵巢癌、胶质母细胞瘤、胃肠道间质瘤、急性髓系白血病和胰腺腺癌等。在本综述中，我们重点关注USP32在不同肿瘤类型中的多种机制，并显示USP32控制许多不同蛋白质的稳定性。因此，USP32是肿瘤治疗中的一个关键和有前景的治疗靶点，可以为抗肿瘤药物研发提供重要的新见解和途径。USP32在癌症治疗中的治疗重要性仍需进一步证明。总之，USP32研究的未来方向有许多选择。© 2023. 细胞死亡与分化协会（ADMC）。

An essential protein regulatory system in cells is the ubiquitin-proteasome pathway. The substrate is modified by the ubiquitin ligase system (E1-E2-E3) in this pathway, which is a dynamic protein bidirectional modification regulation system. Deubiquitinating enzymes (DUBs) are tasked with specifically hydrolyzing ubiquitin molecules from ubiquitin-linked proteins or precursor proteins and inversely regulating protein degradation, which in turn affects protein function. The ubiquitin-specific peptidase 32 (USP32) protein level is associated with cell cycle progression, proliferation, migration, invasion, and other cellular biological processes. It is an important member of the ubiquitin-specific protease family. It is thought that USP32, a unique enzyme that controls the ubiquitin process, is closely linked to the onset and progression of many cancers, including small cell lung cancer, gastric cancer, breast cancer, epithelial ovarian cancer, glioblastoma, gastrointestinal stromal tumor, acute myeloid leukemia, and pancreatic adenocarcinoma. In this review, we focus on the multiple mechanisms of USP32 in various tumor types and show that USP32 controls the stability of many distinct proteins. Therefore, USP32 is a key and promising therapeutic target for tumor therapy, which could provide important new insights and avenues for antitumor drug development. The therapeutic importance of USP32 in cancer treatment remains to be further proven. In conclusion, there are many options for the future direction of USP32 research.© 2023. Cell Death Differentiation Association (ADMC).