低级别炎症（LGI）评分是慢性LGI的一项新指标，结合了C-反应蛋白（CRP），白细胞计数，中性粒细胞/淋巴细胞比（NLR）和血小板（PLT）计数，用于预测心血管疾病，癌症和神经退行性疾病等各种病情的患者的预后。然而，目前很少有研究探讨了LGI评分在预测缺血性中风患者功能预后方面的作用。本研究旨在评估LGI评分与缺血性中风患者功能预后的关联。本研究共筛选了1215名患者，并根据纳入和排除标准最终纳入了876名患者进行回顾性观察研究。血液检测在入院后24小时内进行。使用NIHSS评分评估缺血性中风的严重程度，NIHSS评分＞5表示严重中风。早期神经功能恶化（END）定义为入院后7天内NIHSS总分增加≥2分。患者的预后在中风发作后的第90天使用改良Rankin量表（mRS）进行评估。LGI评分与基线和第7天的NIHSS评分呈正相关（R2 = 0.119，p <0.001；R2 = 0.123，p <0.001）。多元回归分析显示，LGI评分是中风严重程度和END的独立预测因子。在粗模型中，第四个四分位数的LGI评分与第一个四分位数的LGI评分相比，与第90天的不良预后风险更高（OR = 5.02，95％CI：3.09-8.14，p趋势＜0.001）。在调整了潜在混杂因素后，第四个四分位数的LGI评分仍然独立与第90天的不良预后相关（OR = 2.65，95％CI：1.47-4.76，p趋势= 0.001）。最后，ROC曲线分析显示，在中风发作后的第90天预测不良预后的AUC为0.682。LGI评分与急性缺血性中风的严重程度密切相关，LGI评分可能是缺血性中风患者第90天不良预后的良好预测指标。 ©2023. BioMed Central Ltd，Springer Nature的一部分。

The low-grade inflammation (LGI) score, a novel indicator of chronic LGI, combines C-reactive protein (CRP), leukocyte counts, the neutrophil/lymphocyte ratio (NLR), and the platelet (PLT) count to predict outcomes of patients with various conditions, such as cardiovascular diseases, cancers, and neurodegenerative diseases. However, few studies have examined the role of the LGI score in predicting functional outcomes of patients with ischemic stroke. The present study aimed to evaluate the association between the LGI score and functional outcomes of patients with ischemic stroke.A total of 1,215 patients were screened in the present study, and 876 patients were finally included in this retrospective observational study based on the inclusion and exclusion criteria. Blood tests were conducted within 24 h of admission. Severity of ischemic stroke was assessed using the NIHSS score with severe stroke denoted by NIHSS > 5. Early neurological deterioration (END) was defined as an increment in the total NIHSS score of ≥ 2 points within 7 days after admission. Patient outcomes were assessed on day 90 after stroke onset using the modified Rankin Scale (mRS).The LGI score was positively correlated with baseline and the day 7 NIHSS scores (R2 = 0.119, p < 0.001;R2 = 0.123, p < 0.001). Multivariate regression analysis showed that the LGI score was an independent predictor of stroke severity and END. In the crude model, the LGI score in the fourth quartile was associated with a higher risk of poor outcomes on day 90 compared with the LGI score in the first quartile (OR = 5.02, 95% CI: 3.09-8.14, p for trend < 0.001). After adjusting for potential confounders, the LGI score in the fourth quartile was independently associated with poor outcomes on day 90 (OR = 2.65, 95% CI: 1.47-4.76, p for trend = 0.001). Finally, the ROC curve analysis showed an AUC of 0.682 for poor outcomes on day 90 after stroke onset.The LGI score is strongly correlated with the severity of acute ischemic stroke and that the LGI score might be a good predictor for poor outcomes on day 90 in patients with acute ischemic stroke.© 2023. BioMed Central Ltd., part of Springer Nature.