癌症中嗜中性粒细胞的进化和异质性：起源、亚群、功能、协调和临床应用。
The evolution and heterogeneity of neutrophils in cancers: origins, subsets, functions, orchestrations and clinical applications.
发表日期：2023 Sep 07
作者：
Siyao Liu, Wenchuan Wu, Yueshan Du, Hanlin Yin, Qiangda Chen, Weisheng Yu, Wenquan Wang, Jun Yu, Liang Liu, Wenhui Lou, Ning Pu
来源：
Molecular Cancer
摘要：
中性粒细胞是人体内最常见的先天免疫细胞，在近年来由于参与肿瘤进展而受到广泛关注。本综述旨在从整个生命周期的角度阐明中性粒细胞在肿瘤中的重要作用和潜在机制，从骨髓发育、循环到肿瘤微环境（TME）的过程中对其进行追踪。基于对其异质性的理解，我们描述了异常中性粒细胞与肿瘤临床表现之间的关系。具体而言，我们探索了TME内中性粒细胞的功能、起源和极化。此外，我们还对中性粒细胞与临床管理之间的复杂关系进行了广泛分析，包括基于中性粒细胞的临床治疗策略。总之，我们坚信将未来的研究重点放在理解中性粒细胞展示的显著异质性上是至关重要的。© 2023. BioMed Central Ltd., part of Springer Nature.
Neutrophils, the most prevalent innate immune cells in humans, have garnered significant attention in recent years due to their involvement in cancer progression. This comprehensive review aimed to elucidate the important roles and underlying mechanisms of neutrophils in cancer from the perspective of their whole life cycle, tracking them from development in the bone marrow to circulation and finally to the tumor microenvironment (TME). Based on an understanding of their heterogeneity, we described the relationship between abnormal neutrophils and clinical manifestations in cancer. Specifically, we explored the function, origin, and polarization of neutrophils within the TME. Furthermore, we also undertook an extensive analysis of the intricate relationship between neutrophils and clinical management, including neutrophil-based clinical treatment strategies. In conclusion, we firmly assert that directing future research endeavors towards comprehending the remarkable heterogeneity exhibited by neutrophils is of paramount importance.© 2023. BioMed Central Ltd., part of Springer Nature.