纳米技术在制药研究中引起了极大的关注。纳米技术用于开发尺寸在1-100纳米范围内的纳米颗粒，具有几个非凡的特性。金属纳米颗粒(MNPs)在分子生物学、生物传感器、生物成像、生物医学器械、诊断、制药等多个领域得到了应用。本研究通过系统搜索和筛选文献，确定了关注金属纳米颗粒合成的物理、化学和生物方法及其药物应用的文章和专利。本综述共收入了174篇参考文献，其中包括23篇最近的专利。随后，从中筛选出29篇论文来描述其合成的优势、劣势以及物理和化学方法，还选择了28篇文章来提供从细菌、藻类、真菌和植物中制备金属纳米颗粒的生物方法及其详细的合成过程数据。此外，27篇文章概述了金属纳米颗粒的多种临床应用，包括其抗菌、抗癌活性及其在药物传递中的应用。已有多篇综述涵盖了金属纳米颗粒的合成及其药物应用。然而，本综述提供了最新的研究数据，介绍了其开发过程中采用的各种方法。它还总结了不同植物成分在抗癌、抗菌药物传递和其他方面的各种优势和临床应用。还介绍了该领域多位科学家之前的专利概述。本综述将有助于增加当前的知识并激发纳米颗粒的创新，以实现植物成分的精确和靶向输送，用于治疗多种疾病。 版权所有© Bentham Science Publishers；有任何问题，请发送邮件至epub@benthamscience.net。

Nanotechnology has gained enormous attention in pharmaceutical research. Nanotechnology is used in the development of nanoparticles with sizes ranging from 1-100nm, with several extraordinary features. Metallic nanoparticles (MNPs) are used in various areas, such as molecular biology, biosensors, bio imaging, biomedical devices, diagnosis, pharmaceuticals, etc., for their specific applications.For this study, we have performed a systematic search and screening of the literature and identified the articles and patents focusing on various physical, chemical, and biological methods for the synthesis of metal nanoparticles and their pharmaceutical applications.A total of 174 references have been included in this present review, of which 23 references for recent patents were included. Then, 29 papers were shortlisted to describe the advantages, disadvantages, and physical and chemical methods for their synthesis, and 28 articles were selected to provide the data for biological methods for the formulation of metal NPs from bacteria, algae, fungi, and plants with their extensive synthetic procedures. Moreover, 27 articles outlined various clinical applications of metal NPs due to their antimicrobial and anticancer activities and their use in drug delivery.Several reviews are available on the synthesis of metal nanoparticles and their pharmaceutical applications. However, this review provides updated research data along with the various methods employed for their development. It also summarizes their various advantages and clinical applications (anticancer, antimicrobial drug delivery, and many others) for various phytoconstituents. The overview of earlier patents by several scientists in the arena of metallic nanoparticle preparation and formulation is also presented. This review will be helpful in increasing the current knowledge and will also inspire to innovation of nanoparticles for the precise and targeted delivery of phytoconstituents for the treatment of several diseases.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.