口腔鳞状细胞癌(OSCC)是头颈部癌症中最常见的类型之一。尽管有遗传和环境风险因素，但OSCC也与微生物感染和/或菌群紊乱相关。分泌的唾液作为口腔化学屏障，由于OSCC可以改变唾液的蛋白质组成，我们的目标是分析OSCC对唾液化学屏障蛋白的影响。我们收集和检查了关于OSCC患者和对照组的唾液蛋白分析的公开数据集，以识别差异表达的化学屏障蛋白。还进行了差异表达的化学屏障蛋白的网络分析和基因本体(GO)分类。发现了127种在OSCC组和对照组之间显示不同表达模式的蛋白质。构建和分析了上调和下调蛋白质的蛋白质-蛋白质相互作用网络。还确定了主要的中心蛋白质(IL-6、IL-1B、IL-8、TNF、APOA1、APOA2、APOB、APOC3、APOE和HP)并检查了富集的GO术语。我们的研究突出了唾液化学屏障在OSCC发展中的重要性。

Oral squamous cell carcinoma (OSCC) is one of the most frequent types of head and neck cancer. Despite the genetic and environmental risk factors, OSCC is also associated with microbial infections and/or dysbiosis. The secreted saliva serves as the chemical barrier of the oral cavity and, since OSCC can alter the protein composition of saliva, our aim was to analyze the effect of OSCC on the salivary chemical barrier proteins. Publicly available datasets regarding the analysis of salivary proteins from patients with OSCC and controls were collected and examined in order to identify differentially expressed chemical barrier proteins. Network analysis and gene ontology (GO) classification of the differentially expressed chemical barrier proteins were performed as well. One hundred and twenty-seven proteins showing different expression pattern between the OSCC and control groups were found. Protein-protein interaction networks of up- and down-regulated proteins were constructed and analyzed. The main hub proteins (IL-6, IL-1B, IL-8, TNF, APOA1, APOA2, APOB, APOC3, APOE, and HP) were identified and the enriched GO terms were examined. Our study highlighted the importance of the chemical barrier of saliva in the development of OSCC.