具有嵌入阿霉素的磁感控制的透明质酸-磁铁矿纳米复合材料。
Magnetically Controlled Hyaluronic Acid-Maghemite Nanocomposites with Embedded Doxorubicin.
发表日期：2023 Sep 04
作者：
Vasily Spiridonov, Zukhra Zoirova, Yuliya Alyokhina, Nikolai Perov, Mikhail Afanasov, Denis Pozdyshev, Daria Krjukova, Alexander Knotko, Vladimir Muronetz, Alexander Yaroslavov
来源：
PHARMACOLOGY & THERAPEUTICS
摘要：
药物的可控释放是药理学的一个关键任务。为此，通过交联透明质酸和透明质酸/聚丙烯酸酯混合物与Fe2O3纳米颗粒，合成了一系列聚合物复合材料。交联赋予复合材料磁性特性，与透明质酸/Fe2O3复合材料相比，三元透明质酸/聚丙烯酸酯/γ-Fe2O3复合材料的磁性更为显著。当分散于水中时，复合材料形成微米级水凝胶颗粒。以400 T的磁通密度具备磁性的外部永磁体，能够在速度为1.84 cm/s的水溶液中阻止三元微凝胶的循环。复合水凝胶能够吸收抗肿瘤抗生素阿霉素（Dox）；由此制备的结构显示出对肿瘤细胞的细胞毒性与Dox本身的细胞毒性相当。透明质酸酶的添加导致二元和三元微胶凝胶降解为较小颗粒。该研究为制备可被磁性控制的可生物降解聚合物载体以封装生物活性物质提供了展望。
The controllable delivery of drugs is a key task of pharmacology. For this purpose, a series of polymer composites was synthesized via the cross-linking of hyaluronate and a hyaluronate/polyacrylate mixture with Fe2O3 nanoparticles. The cross-linking imparts magnetic properties to the composites, which are more pronounced for the ternary hyaluronate/polyacrylate/γ-Fe2O3 composites compared with the binary hyaluronate/Fe2O3 composites. When dispersed in water, the composites produce microsized hydrogel particles. Circulation of the ternary microgels in an aqueous solution at a speed of 1.84 cm/s can be stopped using a permanent external magnet with a magnetic flux density of 400 T. The composite hydrogels can absorb the antitumor antibiotic doxorubicin (Dox); the resulting constructs show their cytotoxicity to tumor cells to be comparable to the cytotoxicity of Dox itself. The addition of the hyaluronidase enzyme induces degradation of the binary and ternary microgels down to smaller particles. This study presents prospectives for the preparation of magnetically controlled biodegradable polymer carriers for the encapsulation of bioactive substances.