我们的研究旨在调查盐酸双氯芬酸对癫痫样活动的电生理学和抗炎作用，该药物为双氯芬酸的液体形式，在临床上常用于通过抑制环氧合酶酶（COX）抑制炎症过程。2-4个月龄的Wistar大鼠被分为癫痫、地西泮、盐酸双氯芬酸和地西泮+盐酸双氯芬酸组。在麻醉下，青霉素注入大脑皮层后的30分钟内，静脉腔内给予地西泮和盐酸双氯芬酸。在皮层中进行电生理记录了125分钟后，用ELISA评估血清中的白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）的水平。研究结果表明，血清中的IL-1β、IL-6和TNF-α值在各组之间无显著差异。同时，与单独使用盐酸双氯芬酸相比，盐酸双氯芬酸与地西泮联合给药，在51-55、56-60、61-65、111-115和116-120分钟时对于降低脉冲振幅更为有效（p＜0.05）。单剂量的盐酸双氯芬酸未对癫痫样活动产生抗炎作用，但地西泮和盐酸双氯芬酸均能减少癫痫样活动。 © 2023 The Authors. Physiological Reports由Wiley Periodicals LLC代表The Physiological Society和the American Physiological Society出版。

The aim of our study is to investigate the electrophysiological and anti-inflammatory effects of diclofenac potassium on epileptiform activity, which is the liquid form of diclofenac, and frequently used clinically for inflammatory process by inhibiting cyclooxygenase enzyme (COX). Wistar rats aged 2-4 months were divided into Epilepsy, Diazepam, Diclofenac potassium, and Diazepam+diclofenac potassium groups. Diazepam and diclofenac potassium were administered intraperitoneally 30 min after the epileptiform activity was created with penicillin injected intracortically under anesthesia. After the electrophysiological recording was taken in the cortex for 125 min, interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) were evaluated by the ELISA in the serums. No change was observed between the groups in serum IL-1β, IL-6, and TNF-α values. It was observed that the co-administration of diclofenac potassium and diazepam at 51-55, 56-60, 61-65, 111-115, and 116-120 min was more effective in reducing spike amplitude than diclofenac potassium alone (p < 0.05). Single-dose diclofenac potassium did not have an anti-inflammatory effect in epileptiform activity but both diazepam and diclofenac potassium reduced the epileptiform activity.© 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.