人类发展的必然趋势是平均寿命延长和人口老龄化的加剧。在一个老龄化社会中，与老年人医疗保健有关的各种问题日益突出。然而，大多数与年龄相关的疾病具有多种疾病同时存在的特点，容易并发症，并且临床表现不典型，给其治疗带来了巨大困难。甘草黄素（3,5,7-三羟基黄酮）是从海南姜黄根中提取的一种天然活性化合物。最近的许多研究表明，甘草黄素在老年人常见的神经退行性疾病以及心血管和脑血管疾病的治疗中具有潜在的优势。此外，研究还表明甘草黄素在肿瘤、糖尿病、肝损伤、哮喘和关节炎的治疗中也具有前景活性。本综述旨在系统总结和讨论甘草黄素在治疗与年龄相关的疾病中的效果和潜在机制。我们搜索了PubMed、SciFinder、Web of Science和CNKI文献数据库资源，并结合关键词“甘草黄素”、“神经退行性疾病”、“肿瘤”、“糖尿病”、“药理活性”、“药物联用”、“药代动力学”、“药物输送系统”和“安全性”，综合评述了甘草黄素在治疗与年龄相关的疾病中的药理活性和机制。根据以前关于甘草黄素的研究，讨论了其抗神经退行性活性、心血管和脑血管保护活性、抗肿瘤活性、抗糖尿病活性、抗关节炎活性、肝保护活性和抗哮喘活性，并详细归类和总结了相关机制。此外，进一步讨论了甘草黄素的药物联用、药代动力学、药物输送系统和安全性。本综述将为甘草黄素在治疗与年龄相关的疾病中提供参考。同时，还需要进一步的实验研究和长期临床试验来确定甘草黄素的治疗安全性和疗效。版权所有 © 2023 Elsevier GmbH。保留所有权利。

The extension of average life expectancy and the aggravation of population aging have become the inevitable trend of human development. In an aging society, various problems related to medical care for the elderly have become increasingly prominent. However, most of the age-related diseases have the characteristics of multiple diseases at the same time, prone to complications, and atypical clinical manifestations, which bring great difficulties to its treatment. Galangin (3,5,7-trihydroxyflavone) is a natural active compound extracted from the root of Alpinia officinarum Hance (Zingiberaceae). Recently, many studies have shown that galangin has potential advantages in the treatment of neurodegenerative diseases and cardiovascular and cerebrovascular diseases, which are common in the elderly. In addition, it also showed that galangin had prospective activities in the treatment of tumor, diabetes, liver injury, asthma and arthritis.This review aims to systematically summarize and discuss the effects and the underlying mechanism of galangin in the treatment of age-related diseases.We searched PubMed, SciFinder, Web of Science and CNKI literature database resources, combined with the keywords "galangin", "neurodegenerative disease", "tumor", "diabetes", "pharmacological activity", "drug combination", "pharmacokinetics", "drug delivery system" and "safety", and comprehensively reviewed the pharmacological activities and mechanism of galangin in treating age-related diseases.According to the previous studies on galangin, the anti-neurodegenerative activity, cardiovascular and cerebrovascular protective activity, anti-tumor activity, anti-diabetes activity, anti-arthritis activity, hepatoprotective activity and antiasthmatic activity of galangin were discussed, and the related mechanisms were classified and summarized in detail. In addition, the drug combination, pharmacokinetics, drug delivery system and safety of galangin were furtherly discussed.This review will provide reference for galangin in the treatment of age-related diseases. Meanwhile, further experimental research and long-term clinical trials are needed to determine the therapeutic safety and efficacy of galangin.Copyright © 2023 Elsevier GmbH. All rights reserved.