研究表明，胰腺癌的患病率在长期2型糖尿病患者中增加了1.5至2.0倍。本研究旨在评估胰腺癌患者中糖尿病的患病率，并确定与该人群中2型糖尿病相关的因素。本回顾性观察性与分析性研究在Mohammed VI大学医院消化科进行，为期5年，从2018年至2022年，包括所有已确认胰腺腺癌病例的患者。在197名患者中，有38.1%有糖尿病病史，其中42.7%为新发糖尿病，剩余的57.3%为长期糖尿病。糖尿病患者的年龄显著大于非糖尿病患者（平均年龄为67.2岁 vs. 63岁，P = 0.009）。肥胖患者中糖尿病患者的患病率更高（66.7%，P = 0.01），而慢性饮酒者和吸烟者中糖尿病患病率较低（20% vs. 80%，P = 0.04；24.4% vs. 75.6%，P = 0.03）。在ECOG评分≥3的患者中，有54.5%是糖尿病患者（P = 0.033）。营养风险指数方面，具有中度或严重营养不良的患者更可能患糖尿病（74.7%，P = 0.004）。糖尿病患者由于合并症和整体健康恶化而较少接受手术。然而，在性别、肿瘤分期或部位方面没有观察到显著差异。我们的研究显示了胰腺癌中糖尿病的高发现率，并强调在近期发生或控制不佳的糖尿病病例中，特别是在老年人中考虑该癌症的重要性。© 2023 BioMed Central Ltd., part of Springer Nature.

Studies investigating the prevalence of pancreatic cancer have revealed a heightened risk of 1.5 to 2.0 times among individuals with long-standing type 2 diabetes mellitus.We aimed to estimate the prevalence of diabetes among patients with pancreatic cancer, and identify the factors associated with type 2 diabetes mellitus in this population.This retrospective observational and analytical study was carried out in the Department of Gastroenterology of the Mohammed VI University Hospital over a period of 5 years, between 2018 and 2022, including all patients with confirmed cases of pancreatic adenocarcinoma.Out of the 197 patients, 38.1% had a history of diabetes, among them, 42.7% had new-onset diabetes, while the remaining 57.3% had long-standing diabetes. Diabetic patients were significantly older than nondiabetic patients (mean age of 67.2 vs. 63, P = 0.009). Diabetes was more prevalent among obese patients (66.7%, P = 0.01), and less frequent among individuals with chronic alcohol consumption (20% vs. 80%, P = 0.04), and tobacco smokers (24.4% vs75.6%, P = 0.03). Among patients with an ECOG score ≥ 3, DM, 54.5% were DM-patients (P = 0.033). The same significant association was found for the Nutritional Risk Index, Patients who had moderate or severe malnutrition were more likely to be diabetic 74.7% (P = 0.004). Diabetic patients were less likely to undergo surgery due to comorbidities and general health deterioration. However, no significant differences were observed in sex, tumor stage or location.Our study has shown an increased prevalence of diabetes in pancreatic cancer and highlights the importance of considering this cancer in cases of recent onset or uncontrolled diabetes, especially in elderly individuals.© 2023. BioMed Central Ltd., part of Springer Nature.