胰腺癌中KRASG12D的抑制: Fas表达促进免疫清除。
KRASG12D inhibition in pancreatic cancer: Fas expression facilitates immune clearance.
发表日期：2023 Sep 11
作者：
Celine Yeh, Wungki Park, Rona Yaeger
来源：
Epigenetics & Chromatin
摘要：
在《发育细胞》期刊的一篇文章和《癌症细胞》的另一篇论文中，Mahadevan等证明了KrasG12D抑制重塑了KrasG12D胰腺癌的免疫抑制微环境，招募激活的CD8+细胞毒性T细胞，并通过表观遗传学上调Fas表达，导致通过Fas/FasL介导的凋亡清除肿瘤。版权所有© 2023 Elsevier Inc. 保留所有权利。
In an article in this issue of Developmental Cell and in a second paper in Cancer Cell, Mahadevan et al. demonstrate that KrasG12D suppression remodels the immunosuppressive microenvironment of KrasG12D pancreatic cancers, recruits activated CD8+ cytotoxic T cells, and epigenetically upregulates Fas expression in cancer cells, leading to tumor clearance via Fas/FasL-mediated apoptosis.Copyright © 2023 Elsevier Inc. All rights reserved.