光热免疫治疗（PTI）已被证明是一种有前景的癌症治疗方法，然而其疗效常常受到免疫抑制性肿瘤微环境（TME）的影响。本文提出了一种基于镍纳米晶饰以介孔二氧化硅纳米颗粒（RuNC-MSN）的肿瘤光热免疫治疗多功能平台。通过精确调节RuNC在MSN上的距离，实现了RuNC表面等离子体共振的显著增强，从而显著提高了RuNC-MSN的光热效率。此外，RuNC-MSN的自身过氧化酶样活性使其能够有效调节免疫抑制性TME，从而促进光热效应介导的免疫原性细胞死亡（ICD）引发的增强免疫应答。因此，RuNC-MSN展示了卓越的PTI性能，显著抑制了原发肿瘤和转移。我们的研究突出了具有耦合效应增强表面等离子体共振的PTI药剂的合理设计，实现了ICD的同时调节免疫抑制性TME，从而显著提高了PTI的疗效。本文受版权保护。保留所有权利。

Photothermal immunotherapy (PTI) has emerged as a promising approach for cancer treatment, while its efficacy is often hindered by the immunosuppressive tumor microenvironment (TME). Here, we present a multifunctional platform for tumor PTI based on ruthenium nanocrystal-decorated mesoporous silica nanoparticles (RuNC-MSN). By precisely regulating the distance between RuNC on MSN, we achieve a remarkable enhancement in surface plasmon resonance of RuNC, leading to a significant improvement in the photothermal efficiency of RuNC-MSN. Furthermore, the inherent catalase-like activity of RuNC-MSN enables effective modulation of the immunosuppressive TME, thereby facilitating an enhanced immune response triggered by the photothermal effect-mediated immunogenic cell death (ICD). As a result, RuNC-MSN exhibits superior PTI performance, resulting in pronounced inhibition of primary tumor and metastasis. Our study highlights the rational design of PTI agents with coupling effect-enhanced surface plasmon resonance, enabling simultaneous induction of ICD and regulation of the immunosuppressive TME, thereby significantly boosting PTI efficacy. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.