最近，评估身体组成作为癌症患者预后标志物的兴趣日益增长。在接受自体造血干细胞移植（HSCT）的非霍奇金淋巴瘤（NHL）患者中，身体组成参数与预后的关联尚未深入研究。我们进行了一项回顾性队列研究，纳入了264名接受自体HSCT的NHL患者。对L3水平处的术前腹部CT扫描进行身体组成测量。我们评估了肌肉衰减、肌肉脂肪浸润、高内脏脂肪（VAT）和高内脏脂肪密度（VATD）。使用多变量Cox比例风险回归分析，我们分析了临床和移植相关特征与总生存期（OS）、无复发生存期（RFS）和非复发性死亡率（NRM）的关联。在多元回归模型中，VATD较高的患者比VATD较低的患者具有更差的总生存期（HR 1.78；95%置信区间CI 1.08-2.95，p=0.02）和更高的非复发性死亡率（HR 2.31；95% CI 1.08-4.95，p=0.02）。VAT水平较低的患者也具有更差的无复发生存期（HR 1.49；95% CI 1.03-2.15，p=0.03）。肌肉衰减和肌肉脂肪浸润与预后结果无关。NHL患者接受自体HSCT中，术前高内脏脂肪密度与较低的总生存期和较高的非复发性死亡率相关，术前低内脏脂肪与较差的无复发生存期相关。© 2023. 作者通过排他性许可协议授予Springer Nature Limited。

Recently there has been a growing interest in evaluating body composition as a marker for prognosis in cancer patients. The association of body composition parameters and outcomes has not been deeply investigated in patients with autologous hematopoietic stem cell transplantation (HSCT) recipients with non-Hodgkin lymphoma (NHL). We conducted a retrospective cohort study of 264 NHL patients who received autologous HSCT. PreHSCT abdominal CT scans at the levels of L3 were assessed for body composition measures. We evaluated sarcopenia, myosteatosis, high visceral adipose tissue (VAT) and high visceral adipose tissue density (VATD). Using multivariable Cox proportional regression, we analyzed the association of clinical and transplant-related characteristics with overall survival (OS), relapse-free survival (RFS), and non-relapse mortality (NRM). In a multivariate regression model, patients with higher VATD had worse OS (HR 1.78; 95% confidence intervals CI 1.08-2.95, p = 0.02) and worse NRM (HR 2.31 95% CI 1.08-4.95, p = 0.02) than with lower VATD. Patients with lower levels of VAT also had worse RFS (HR 1.49 95% CI 1.03-2.15, p = 0.03). Sarcopenia and myosteatosis were not associated with outcomes. High pre-transplant VATD was associated with lower OS and higher NRM, and low pre-transplant VAT was associated with worse RFS in patients with NHL undergoing autologous HSCT.© 2023. The Author(s), under exclusive licence to Springer Nature Limited.