心脏磁共振生物标志物作为心脏疾病临床试验中的替代终点。
Cardiac magnetic resonance biomarkers as surrogate endpoints in cardiovascular trials for myocardial diseases.
发表日期:2023 Sep 13
作者:
Dominik C Benz, Christoph Gräni, Panagiotis Antiochos, Bobak Heydari, Mark Colin Gissler, Yin Ge, Sarah A M Cuddy, Sharmila Dorbala, Raymond Y Kwong
来源:
EUROPEAN HEART JOURNAL
摘要:
心脏磁共振成像在心肌疾病的诊断、风险分层和治疗中提供了多个方面的应用。特别是其精确监测疾病活动的特性,使其能够量化对新型治疗方案的反应。本综述重点评估心脏磁共振成像生物标志物作为前瞻性临床试验的替代终点的价值。主要关注的是全面概述建立的心脏磁共振参数在心肌疾病中的价值。其中包括心力衰竭、心脏淀粉样变、铁负荷性心肌病、肥厚型心肌病、心脏肿瘤病、以及心肌炎和肺结节病等炎性心肌病。© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Cardiac magnetic resonance offers multiple facets in the diagnosis, risk stratification, and management of patients with myocardial diseases. Particularly, its feature to precisely monitor disease activity lends itself to quantify response to novel therapeutics. This review critically appraises the value of cardiac magnetic resonance imaging biomarkers as surrogate endpoints for prospective clinical trials. The primary focus is to comprehensively outline the value of established cardiac magnetic resonance parameters in myocardial diseases. These include heart failure, cardiac amyloidosis, iron overload cardiomyopathy, hypertrophic cardiomyopathy, cardio-oncology, and inflammatory cardiomyopathies like myocarditis and sarcoidosis.© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.