皮西坦诺尔（Piceatannol）是一种天然存在的羟基化白藜芦醇类似物，可在各种水果和蔬菜中找到。已有文献记录了它具有广泛的有益作用，包括抗炎、抗氧化、抗衰老、抗过敏、抗糖尿病、神经保护、心脏保护和化学预防特性。与白藜芦醇相比，皮西坦诺尔具有显著较高的抗氧化活性。在临床前研究中，皮西坦诺尔已被证明能够抑制或减少大脑、乳房、肺、结肠、宫颈、肝脏、前列腺和皮肤等多种器官的癌症生长。然而，与白藜芦醇和其他苯乙烯类化合物相比，皮西坦诺尔的生物利用度较低。近年来报道了几种提高其生物利用度和生物活性的方法，需要进行临床试验来验证这些发现。本综述聚焦于天然苯乙烯类化合物皮西坦诺尔的化学特性、作用机制及其在预防和治疗各种复杂人类疾病中的潜在治疗作用。© 2023国际生物化学与分子生物学联合会。

Piceatannol is a naturally occurring hydroxylated resveratrol analogue that can be found in a variety of fruits and vegetables. It has been documented to have a wide range of beneficial effects, including anti-inflammatory, antioxidant, anti-aging, anti-allergic, antidiabetic, neuroprotective, cardioprotective, and chemopreventive properties. Piceatannol has significantly higher antioxidant activity than resveratrol. Piceatannol has been shown in preclinical studies to have the ability to inhibit or reduce the growth of cancers in various organs such as the brain, breast, lung, colon, cervical, liver, prostate, and skin. However, the bioavailability of Piceatannol is comparatively lower than resveratrol and other stilbenes. Several approaches have been reported in recent years to enhance its bioavailability and biological activity, and clinical trials are required to validate these findings. This review focuses on several aspects of natural stilbene Piceatannol, its chemistry, and its mechanism of action, and its promising therapeutic potential for the prevention and treatment of a wide variety of complex human diseases.© 2023 International Union of Biochemistry and Molecular Biology.